Long-Term Follow-up Results of the DANTE Trial, a Randomized Study of Lung Cancer Screening with Spiral Computed Tomography

American Journal of Respiratory and Critical Care Medicine
Maurizio InfanteDANTE Study Group

Abstract

Screening for lung cancer with low-dose spiral computed tomography (LDCT) has been shown to reduce lung cancer mortality by 20% compared with screening with chest X-ray (CXR) in the National Lung Screening Trial, but uncertainty remains concerning the efficacy of LDCT screening in a community setting. To explore the effect of LDCT screening on lung cancer mortality compared with no screening. Secondary endpoints included incidence, stage, and resectability rates. Male smokers of 20+ pack-years, aged 60 to 74 years, underwent a baseline CXR and sputum cytology examination and received five screening rounds with LDCT or a yearly clinical review only in a randomized fashion. A total of 1,264 subjects were enrolled in the LDCT arm and 1,186 in the control arm. Their median age was 64.0 years (interquartile range, 5), and median smoking exposure was 45.0 pack-years. The median follow-up was 8.35 years. One hundred four patients (8.23%) were diagnosed with lung cancer in the screening arm (66 by CT), 47 of whom (3.71%) had stage I disease; 72 control patients (6.07%) were diagnosed with lung cancer, with 16 (1.35%) being stage I cases. Lung cancer mortality was 543 per 100,000 person-years (95% confidence interval, 413-700) in the LD...Continue Reading

References

Feb 15, 1991·Cancer·R S FontanaE J Bergstralh
Sep 1, 1993·Cancer·B J FlehingerM R Melamed
Mar 1, 1997·Chest·G M StraussD J Sugarbaker
Nov 30, 2000·The New England Journal of Medicine·E F PatzG Bepler
Jun 8, 2006·Journal of the National Cancer Institute·Pamela M MarcusRobert S Fontana
Sep 23, 2006·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Dong Ming XuRob van Klaveren
Oct 27, 2006·The New England Journal of Medicine·UNKNOWN International Early Lung Cancer Action Program InvestigatorsOlli S Miettinen
Aug 7, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Shusuke SoneHajime Fushimi
Oct 16, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Maurizio InfanteUNKNOWN DANTE Study Group
Mar 1, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Giulia VeronesiLorenzo Spaggiari
Jul 19, 2008·American Journal of Respiratory and Critical Care Medicine·David O WilsonJill M Siegfried
Aug 30, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Andrea Lopes PegnaUNKNOWN ITALUNG Study Research Group
Apr 10, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Jesper H PedersenNiels Seersholm
May 12, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Ravi J MenezesFrances A Shepherd
Jun 13, 2009·American Journal of Respiratory and Critical Care Medicine·Maurizio InfanteUNKNOWN DANTE Study Group
Dec 4, 2009·The New England Journal of Medicine·Rob J van KlaverenHarry J de Koning
Jul 1, 2011·The New England Journal of Medicine·UNKNOWN National Lung Screening Trial Research TeamJoRean D Sicks
Oct 28, 2011·JAMA : the Journal of the American Medical Association·Martin M OkenUNKNOWN PLCO Project Team
Mar 29, 2012·Radiology·Claudia I HenschkeUNKNOWN Writing Committee for the I-ELCAP Investigators
Apr 3, 2012·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Ugo PastorinoCarlo La Vecchia
May 23, 2012·JAMA : the Journal of the American Medical Association·Peter B BachFrank C Detterbeck
Apr 25, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Andrea Lopes PegnaUNKNOWN ITALUNG Study Research Group
Jul 13, 2013·The European Respiratory Journal·Nanda HorewegHarry J de Koning
Jul 19, 2013·The New England Journal of Medicine·Stephanie A KovalchikHormuzd A Katki
Jul 31, 2013·Journal of Surgical Oncology·John K FieldUNKNOWN European Randomized Screening Trial Group
Sep 6, 2013·The New England Journal of Medicine·Annette McWilliamsStephen Lam
Feb 25, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J VansteenkisteUNKNOWN Panel Members
Jun 13, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Giulia VeronesiMassimo Bellomi
Jun 14, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Ravi Menezes, Heidi Roberts
Sep 10, 2014·Annals of Internal Medicine·Paul F PinskyBarnett S Kramer
Sep 24, 2014·AJR. American Journal of Roentgenology·Dong Ming XuUNKNOWN I-ELCAP Investigators
Nov 6, 2014·The New England Journal of Medicine·William C BlackUNKNOWN National Lung Screening Trial Research Team
Dec 3, 2014·The Annals of Thoracic Surgery·Joshua E RosenDaniel J Boffa

❮ Previous
Next ❯

Citations

Nov 10, 2015·The American Journal of Medicine·Daniel ShepshelovichMeir Lahav
Aug 22, 2015·International Journal of Molecular Sciences·Filippo LococoSally Maramotti
Sep 9, 2015·International Journal of Cancer. Journal International Du Cancer·Maurizio InfanteMarco Alloisio
Jan 15, 2016·Biomarkers in Medicine·Giulia VeronesiMarco Alloisio
Oct 21, 2015·American Journal of Respiratory and Critical Care Medicine·Mathilde M W WilleJesper H Pedersen
Mar 2, 2016·American Journal of Respiratory and Critical Care Medicine·Anil Vachani, James R Jett
Feb 28, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Ugo PastorinoGiovanni Corrao
Nov 26, 2015·Academic Radiology·Jerome Mark Reich, Jong S Kim
May 3, 2015·Clinical Lung Cancer·Jerome M ReichJames W Asaph
Aug 1, 2015·American Journal of Respiratory and Critical Care Medicine·Maurizio Infante, Silvio Cavuto
Aug 1, 2015·American Journal of Respiratory and Critical Care Medicine·Robert P Young, Raewyn J Hopkins
May 2, 2016·Gaceta sanitaria·Alberto Ruano-RavinaMariano Provencio-Pulla
May 23, 2016·Medicina clínica·Alberto Ruano-RavinaPere Casan Clarà
May 24, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Gaëlle CoureauSimone Mathoulin-Pélissier
Jul 9, 2016·Annals of the American Thoracic Society·Alex A BalekianMichael K Gould
Jul 17, 2012·The Medical Clinics of North America·George R Washko
Jul 28, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Alain MakinsonBernard Milleron
Sep 27, 2016·Clinical Journal of Oncology Nursing·Katelyn HartHsiao-Lan Wang
Aug 22, 2016·Clinical Oncology : a Journal of the Royal College of Radiologists·D R Baldwin, M E J Callister
Oct 23, 2016·Journal of Proteome Research·Ingrid BroodmanTheo Luider
Feb 1, 2017·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Jesper Holst PedersenGaetano Rocco
Jan 28, 2017·American Journal of Respiratory and Critical Care Medicine·Claus F VogelmeierAlvar Agustí
Feb 6, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·Claus F VogelmeierAlvar Agusti
Mar 18, 2017·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Carla VerriMattia Boeri
May 2, 2017·American Journal of Respiratory and Critical Care Medicine·Anil VachaniAvrum Spira
Dec 23, 2016·Expert Review of Respiratory Medicine·Marjolein A HeuvelmansMatthijs Oudkerk
Mar 2, 2017·International Journal of Cancer. Journal International Du Cancer·Marianne WeberKaren Canfell
May 26, 2016·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Maurizio InfanteUgo Pastorino
Jan 9, 2018·Oncoimmunology·Shengxiang RenFred R Hirsch
Apr 6, 2017·Thorax·Eugenio PaciUNKNOWN and the ITALUNG Working Group
Feb 9, 2018·Future Oncology·Cláudia GouvinhasDaniel Humberto Pozza
Jun 22, 2018·Tuberculosis and Respiratory Diseases·Yong Bum ParkUNKNOWN Committee of the Korean COPD Guideline 2018
Jul 28, 2017·The British Journal of Radiology·Emma Louise O'Dowd, David R Baldwin
Oct 12, 2018·International Journal of Radiation Biology·Takeshi Nawa
Nov 2, 2018·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Bernd KowallAndreas Stang
May 10, 2016·F1000Research·David E Midthun
Nov 2, 2015·The European Respiratory Journal·Alberto Ruano-RavinaAlberto Fernández-Villar

❮ Previous
Next ❯

Related Concepts

Related Feeds

American Thoracic Association Journals

Discover the latest respiratory research published by the journals from the American Thoracic Society.

Related Papers

Clinics in Chest Medicine
David E Midthun
Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Maurizio InfanteDANTE Study Group
Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Maurizio InfanteDANTE Study Group
© 2021 Meta ULC. All rights reserved