Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells

Nature Medicine
Janet D SilicianoRobert F Siliciano

Abstract

Latent HIV-1 persists in resting memory CD4+ T cells, even in patients receiving highly active antiretroviral therapy (HAART). It has been unclear how stable this latent reservoir is and whether its persistence reflects replenishment by low-level viremia. Here we show that even in treated patients who have had no detectable viremia for as long as 7 years, the reservoir decays so slowly (t(1/2) = 44 months) that eradication is unlikely.

References

Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·T W ChunA S Fauci
May 26, 1999·The New England Journal of Medicine·L ZhangD D Ho
Nov 30, 1999·JAMA : the Journal of the American Medical Association·G DornadulaR J Pomerantz
Jul 13, 2001·JAMA : the Journal of the American Medical Association·M HermankovaD Persaud
Jan 31, 2002·Annual Review of Medicine·Joel N BlanksonRobert F Siliciano

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Citations

Apr 14, 2010·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Sonia ShahBrian Wigdahl
Aug 9, 2011·Bulletin of Mathematical Biology·Cameron J Browne, Sergei S Pilyugin
May 9, 2012·Bulletin of Mathematical Biology·Jonathan FordeStanca M Ciupe
Jul 11, 2012·Bulletin of Mathematical Biology·Zoë Ward, Jane White
Aug 11, 2005·Current HIV/AIDS Reports·Jeffrey M Jacobson
Jun 6, 2007·Current HIV/AIDS Reports·David M Margolis
Apr 29, 2010·Current HIV/AIDS Reports·David M Margolis
Dec 18, 2012·Current HIV/AIDS Reports·Marta MassanellaJulià Blanco
Jan 14, 2010·Immunologic Research·Rebecca L LamasonJoel L Pomerantz
Feb 4, 2011·Journal of Biosciences·Dwaipayan Adhya, Anirban Basu
Feb 12, 2009·Expert Reviews in Molecular Medicine·Mary-Catherine BowmanDavid M Margolis
Jul 28, 2012·Nature·Steven G Deeks
Nov 16, 2011·Immunology and Cell Biology·Fiona WightmanSharon R Lewin
Sep 5, 2013·Molecular Therapy. Nucleic Acids·Mireille CentlivreBen Berkhout
Jun 23, 2009·Nature Medicine·Nicolas ChomontRafick-Pierre Sékaly
Jul 22, 2005·Nature Reviews. Immunology·Peter J L LaneMi-Yeon Kim
Jul 21, 2012·Nature Reviews. Immunology·Steven G DeeksFrançoise Barré-Sinoussi
Jan 17, 2007·Nature Reviews. Microbiology·Yefei HanRobert F Siliciano
Oct 17, 2009·Nature Reviews. Microbiology·Mayte CoirasJosé Alcamí
Mar 24, 2004·Nature Reviews. Microbiology·Viviana Simon, David D Ho
Apr 30, 2004·The New England Journal of Medicine·Justin StebbingDaniel C Douek
Mar 12, 2008·Proceedings of the National Academy of Sciences of the United States of America·Sarah PalmerMartin S King
Apr 2, 2009·Proceedings of the National Academy of Sciences of the United States of America·Hung-Chih YangJoel L Pomerantz
May 31, 2012·Proceedings of the National Academy of Sciences of the United States of America·Nancie M ArchinAlan S Perelson
Jun 4, 2008·The Journal of Biological Chemistry·Kazuo SuzukiAnthony D Kelleher
Jan 1, 2008·Journal of Biological Dynamics·H T BanksE S Rosenberg
Dec 21, 2012·The Journal of Experimental Medicine·Matthieu PerreauGiuseppe Pantaleo
Aug 19, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M Arnedo-ValeroJ M Gatell
Jun 30, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Bruno HoenUNKNOWN QUEST Study Group
Jan 4, 2008·The Journal of Infectious Diseases·Homer L Twigg IiiUNKNOWN AIDS Clinical Trials Group Protocol 723 Team
Feb 6, 2008·The Journal of Infectious Diseases·Kersten K KoelschJoseph K Wong
Feb 12, 2008·The Journal of Infectious Diseases·Tae-Wook ChunAnthony S Fauci
Feb 12, 2008·The Journal of Infectious Diseases·Steven Yukl, Joseph K Wong
Apr 19, 2008·The Journal of Infectious Diseases·Shailesh K ChoudharyDavid M Margolis
Dec 17, 2009·The Journal of Infectious Diseases·Rajesh T GandhiUNKNOWN AIDS Clinical Trials Group A5173 Team
May 1, 2004·AIDS Research and Human Retroviruses·William J SwiggardMichael H Malim
Mar 3, 2007·AIDS Research and Human Retroviruses·Victor Sanchez-MerinoCecilio Lopez-Galindez
Oct 27, 2007·AIDS Research and Human Retroviruses·Gonzalo BelloCecilio López-Galíndez
Aug 20, 2009·AIDS Research and Human Retroviruses·Eduardo SprinzMarcelo A Soares
May 29, 2010·AIDS Research and Human Retroviruses·Ombretta TurrizianiGuido Antonelli
Aug 14, 2010·AIDS Research and Human Retroviruses·Rowena Johnston
Aug 30, 2013·AIDS Research and Human Retroviruses·Aida SivroT Blake Ball

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