PMID: 176115Mar 15, 1976Paper

Long-term follow-up studies on herpes simplex antibodies in the course of cervical cancer. II. Antibodies to surface antigen of Herpes simplex virus infected cells

International Journal of Cancer. Journal International Du Cancer
B Christenson, A Espmark

Abstract

In a serological follow-up of 88 women with active invasive cervical carcinoma, antibodies to membrane antigen of Herpes simplex virus (HSV)-infected cells were measured by the use of the mixed hemadsorption method. Sera were collected at the time of initial treatment and then at regular intervals. As controls, 85 healthy age-matched women and 70 patients suffering from other types of cancer were tested similarly. During the 6-to 60-month observation period 16 patients in the cervix carcinoma group died. The reactivity with membrane antigen of HSV-infected cells was positive in 71% of the cervical carcinoma patients, whereas the figure for the other cancer group was 27% and for the age-matched control group 27%. In the group of 16 patients who died, only 3 demonstrated antibodies against surface antigens of HSV-infected cells. In most cases radiation treatment of the tumor did not significantly alter the mixed hemadsorption titer but in 10 surviving patients there was a significant increase in reactivity as the tumor was treated; 1 patient who had recurrence of her cancer lost reactivity in later sera. Among the 11 cervix carcinoma patients in stage I (by clinical definition carcinoma strictly confined to the cervix) all but on...Continue Reading

References

Jul 1, 1973·American Journal of Epidemiology·L AurelianC G Julian
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Oct 1, 1971·Proceedings of the Society for Experimental Biology and Medicine·A J NahmiasD Thies
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Jun 7, 1965·JAMA : the Journal of the American Medical Association·F MILGROME WITEBSKY

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Citations

Oct 1, 1977·Australian and New Zealand Journal of Medicine·P Hersey
Nov 1, 1979·CRC Critical Reviews in Microbiology·L S Kucera
Nov 15, 1977·International Journal of Cancer. Journal International Du Cancer·B Christenson
Nov 1, 1976·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L Thiry
May 15, 1981·International Journal of Cancer. Journal International Du Cancer·L N MendisJ E Banatvala
Feb 1, 1979·Postgraduate Medical Journal·C W Potter
Jan 1, 1980·Journal of Immunological Methods·M GrandienL Grillner

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