Nov 25, 2000

Long-term follow-up study of artificial dermis composed of outer silicone layer and inner collagen sponge

British Journal of Plastic Surgery
S SuzukiYoshito Ikada


In the oriental population including the Japanese, donor-site hypertrophy is more pronounced than in Caucasians. To solve the problem of donor-site morbidity and to ensure graft 'take', we started the second-stage procedure of a thin split thickness skin graft (STSG) onto acellular 'bilayer artificial skin', or 'artificial dermis'. Since reporting the original version of the material (OV), a revised version (RV) and the present version (PV, Pelnac) have been developed in stages to eliminate inconveniences associated with its use and to reduce the primary cost of manufacture. We have now used our materials, consisting of OV, RV and PV, on 52 skin defects in 41 patients. STSG took almost perfectly in all patients. The long-term results of these three materials were investigated in 20 patients who had been followed up for more than 2 years, excluding three patients whose donor sites had been directly closed. The longest and the mean follow-up periods of these patients were 12 years 5 months and 6 years 10 months, respectively. At the grafted sites, wrinkles caused by shrinkage, partial depigmentation and hypertrophy were observed in five (25%), one (5%) and one (5%) of the 20 patients, respectively. At the donor sites, slight unsi...Continue Reading

  • References17
  • Citations36


  • References17
  • Citations36


Mentioned in this Paper

Hypopigmentation Disorder
Skin Substitutes
Epiphyseal Dysplasia, Multiple,4
Prosthesis Design
Cicatrix, Hypertrophic
Wound Infection
Skin Transplantation

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