Long-term food restriction down-regulates the density of serotonin transporters in the rat frontal cortex

Biological Psychiatry
G HuetherE Rüther

Abstract

The influence of feeding rats only half the amount of their normal daily intake of a complete rat chow on the affinity and the density of serotonin (5-HT) transporters was measured in membrane preparations of the frontal cortex and the midbrain by a [3H]paroxetine binding assay. In young rats (10 weeks), a significant reduction of about 30% of the Bmax values of [3H]paroxetine binding occurred in the frontal cortex after 1 and 2 weeks of restricted food intake. No starvation-induced decline of the density of 5-HT transporters was seen in the midbrain. When older rats (50 weeks) were subjected to the same 50% reduction of daily food intake for 2 weeks, no such down-regulation of the density of cortical 5-HT transporters was observed. The affinity of the 5-HT transporters, as indicated by the unchanged Kd values of [3H]paroxetine binding, was not affected by semistarvation in both regions and at both ages. The observed decline of [3H]paroxetine binding sites in the frontal cortex of young adult rats is the first demonstration of long-term regulatory phenomena of brain 5-HT transporters triggered by a physiologic stimulus.

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Citations

Apr 12, 2002·The International Journal of Eating Disorders·Daniel M T Fessler
Jan 30, 2013·Experimental and Clinical Psychopharmacology·Jeffrey S SteinGregory J Madden
Apr 21, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Howard SteigerAnne Marie Parent
Jan 13, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Howard SteigerJulie Hakim
May 18, 2011·Forschende Komplementärmedizin = Research in Complementary Medicine·Eugene WilsonGustav Jürgen Dobos
Feb 4, 2005·The International Journal of Eating Disorders·Howard SteigerAdam Torkaman-Zehi
Oct 19, 2011·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Thomas M WrightJörg-Peter W Voigt
May 4, 2011·Journal of Neuroscience Methods·Sandra L Rokosik, T Celeste Napier
May 29, 2014·British Journal of Pharmacology·M A van GestelS K Janhunen
Jun 4, 2002·Nutritional Neuroscience·J M Barreto MedeirosR Manhães De Castro
Aug 7, 1998·Journal of Psychopharmacology·P Schloss, D C Williams
May 13, 2019·MMW Fortschritte der Medizin·Mahmoud Sultan

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