Long-term functional change of cryoinjury-induced detrusor underactivity and effects of extracorporeal shock wave therapy in a rat model

International Urology and Nephrology
Yao-Chi ChuangMichael B Chancellor

Abstract

To investigate the long-term functional change of cryoinjury-induced detrusor underactivity (DU) and the therapeutic potential of repeated low-energy shock wave therapy (LESW). Fifty-six female Sprague-Dawley rats were assigned into sham and cryoinjury of bladder with or without LESW (0.05 or 0.12 mJ/mm2; 200 pulses; twice a week for 2 weeks after cryoinjury). Under halothane anesthesia, an incision was made in lower abdomen, and cryoinjury was provoked by bilateral placement of a chilled aluminum rod on the bladder filled with 1 ml saline. Measurement of contractile responses to KCl and carbachol in vitro, conscious voiding, and histological and protein changes were performed on week 1, 2, and 4 after cryoinjury. Cryoinjury of bladder induced a significant decrease in the detrusor contraction amplitude at week 1 (55.0%) and week 2 (57.2%), but the decrease in the contractile response to KCl and carbachol was only noted at week 1. At week 1, significantly increased COX-2 and TGF-β1 expression accompanied a decrease of VEGF and CGRP expression. At week 4, there was a partial recovery of voiding function and a significant increase in the Ki-67 staining. LESW treatment at higher energy level further amplified the Ki-67 staining an...Continue Reading

References

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Oct 10, 2002·Brain Research Bulletin·George T SomogyiMichael B Chancellor
Apr 25, 2008·The Journal of Urology·Wei-Chia LeeShih-Wei Lee
Apr 29, 2009·Tissue Engineering. Part a·Tetsuya ImamuraOsamu Nishizawa
Oct 13, 2016·The American Journal of Sports Medicine·Angela ZisslerAlexandra M Sänger
Feb 25, 2017·International Urology and Nephrology·Karel DewulfMichael B Chancellor
Jul 12, 2017·International Journal of Urology : Official Journal of the Japanese Urological Association·Hung-Jen WangYao-Chi Chuang
Aug 2, 2017·Neurourology and Urodynamics·Bohan WangTom F Lue

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Citations

Mar 8, 2021·International Neurourology Journal·Fotios DimitriadisApostolos Apostolidis

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