Long-Term Gastrointestinal Consequences are Frequent Following Sporadic Acute Infectious Diarrhea in a Tropical Country: A Prospective Cohort Study

The American Journal of Gastroenterology
Masudur M RahmanShafiqul Alam Sarker

Abstract

Postinfection irritable bowel syndrome (PI-IBS) and functional dyspepsia (PI-FD), though reported from the temperate countries, have not been studied in the tropics; PI-malabsorption syndrome (MAS), which mimics PI-IBS, is reported from the tropics. No report till date on PI-IBS excluded PI-MAS. We studied: (i) the frequency of continuing bowel dysfunction after acute gastroenteritis (AG), (ii) its predictors, and (iii) PI-MAS among patients with PI-IBS. 345 consecutive subjects each, with AG and age- and gender-matched healthy controls were followed up 3-monthly for 12 months using a translated-validated questionnaire and functional gastrointestinal disorders (FGIDs) were diagnosed by Rome III criteria. Symptom duration >3 months but <6 months was diagnosed as chronic bowel dysfunction (CBD) and dyspeptic symptoms, respectively. MAS was diagnosed if 2/3 tests (D-xylose H2 breath test, Sudan III-stained stool microscopy, and duodenal histology) were abnormal. Fecal microbiological studies were performed in 245/345 (71%) patients. AG patients more often developed PI-IBS and PI-FD than controls (16.5 vs. 2.6% and 7.4 vs. 0.6%, respectively; p<0.001). Presence of FD was a risk factor for PI-IBS and IBS for PI-FD. On multivariate a...Continue Reading

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Citations

Apr 6, 2019·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Prasanta Kumar ParidaShivaram Prasad Singh
May 22, 2019·Scandinavian Journal of Gastroenterology·Anna Tølbøll SvendsenAnne Line Engsbro
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May 25, 2021·Gastroenterology Clinics of North America·Antonio BerumenMadhusudan Grover
Oct 22, 2021·Journal of Gastroenterology and Hepatology·Uday C GhoshalFaruque Ahmed

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