PMID: 19920630Feb 1, 1995Paper

Long-term Glaucoma Treatment with MK-507, Dorzolamide, a Topical Carbonic Anhydrase Inhibitor

Journal of Glaucoma
MK-507 Clinical Study Group

Abstract

The purpose of this study was to examine the long-term efficacy and safety of dorzolamide (a topical carbonic anhydrase inhibitor, previously known as MK-507) as an ocular hypotensive agent. This open-labeled, multicenter, 52-week trial enrolled patients with primary open-angle glaucoma or ocular hypertension. One percent dorzolamide hydrochloride was instilled in both eyes of each patient every 8 h. On the 1st day of the study, intraocular pressure (IOP) was measured with a Gold-mann applanation tonometer at 8:30 and 10:30 a.m. Patients were examined at least every 4 weeks. During each clinic visit, dorzolamide was given at 12:30 a.m., and IOP was determined 8 h later. After IOP measurements, dorzolamide was administered again. Further IOP readings were taken 2 h later at 10:30 a.m. Patients were monitored closely by testing for visual acuity, anterior segment, and by continuously evaluating symptoms. Ninety-eight patients entered the study and 81 patients (82.7%) completed the study according to the protocol. Three patients had to be withdrawn because of untoward reactions; two experienced ocular discomfort and one developed palpitation. Four patients required additional ocular hypotensive medication for further IOP reduction...Continue Reading

Citations

Dec 30, 1999·Progress in Retinal and Eye Research·M F Sugrue
Jan 22, 2004·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Makoto AraieHideki Origasa
May 1, 2004·Journal of Glaucoma·Carol B TorisCarl B Camras
Oct 26, 1999·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·M PortellosS F Freedman

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