Abstract
To assess the adjunct effect of metformin to insulin in type 2 diabetes. Obese and overweight type 2 diabetes patients treated with insulin for at least 1 year, and with poor glycaemic control (HbA1c > upper reference level + 2%), were included in a randomised, double-blind, placebo-controlled study. Patients were treated for 12 months with either metformin (850 mg b.i.d.) or placebo added to their usual insulin, which was stabilized during a 3-month placebo run-in period, but thereafter attempted to be unchanged. Thirty-seven patients were included. Two patients dropped out during run-in. There were no differences between the metformin (n = 16) and placebo (n = 19) group at baseline. Most patients received multiple insulin injections. Metabolic control was improved by addition of metformin. Mean change in HbA1c from baseline showed highly significant difference between groups at 3, 6, 9 and 12 months. Mean change (percentage units +/- s.d.) at 12 months was -1.1 +/- 0.7% vs. + 0.3 +/- 0.8% (p < 0.001) for HbA1c and -1.4 +/- 2.1 mmol/l vs. + 0.6 +/- 2.2 mmol/l (p = 0.025) for fasting blood glucose. Mean low density lipoprotein (LDL) cholesterol change differed slightly at 6 months, but not at 12 months. There were no changes in...Continue Reading
References
Nov 12, 1992·The New England Journal of Medicine·H Yki-JärvinenP Seppälä
Sep 1, 1987·Diabetologia·I MühlhauserI Mincu
Oct 1, 1985·Metabolism: Clinical and Experimental·H GinJ Aubertin
Mar 1, 1995·Diabetes Care·C C ChowC S Cockram
Jan 1, 1993·European Journal of Clinical Pharmacology·D GiuglianoF D'Onofrio
Feb 12, 1996·Archives of Internal Medicine·J L JohnsonU M Kabadi
May 1, 1997·Diabetes·J GagnéG Massicotte
Mar 27, 1998·The New England Journal of Medicine·S E InzucchiG I Shulman
May 20, 1998·Diabetes Care·A C RobinsonR S Elkeles
Jun 6, 1998·The British Journal of Psychiatry : the Journal of Mental Science·D J HallH Smith
Nov 20, 1998·Psychosomatics·M Binzer, G Kullgren
Mar 6, 1999·Annals of Internal Medicine·H Yki-JärvinenM Heikkilä
Jul 7, 1999·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·H C Howlett, C J Bailey
Jul 31, 1999·Annals of Internal Medicine·L Avilés-SantaP Raskin
Oct 8, 1999·Diabetic Medicine : a Journal of the British Diabetic Association
Oct 16, 1999·Primary Care·J B Buse
Jul 15, 2004·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·L S Hermann
Citations
Jul 27, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A Golay
Oct 13, 2005·Diabetes, Obesity & Metabolism·Suzanne M Strowig, Philip Raskin
Oct 10, 2006·Diabetes, Obesity & Metabolism·G BiesenbachN Alsaraji
Jan 30, 2009·Diabetes, Obesity & Metabolism·Mariëlle J P van Avendonk, Guy E H M Rutten
May 22, 2010·BMJ : British Medical Journal·Jolien de JagerCoen D A Stehouwer
Apr 18, 2012·PLoS Medicine·Rémy BoussageonCatherine Cornu
Jun 9, 2015·The Lancet. Diabetes & Endocrinology·Avivit CahnStefano Del Prato
Apr 22, 2005·Diabetic Medicine : a Journal of the British Diabetic Association·I F DouekUNKNOWN Metformin Trial Group
Jun 12, 2010·Diabetic Medicine : a Journal of the British Diabetic Association·R A DeFronzoM E Wintle
Jul 9, 2004·Medical Hypotheses·Mark F McCarty
Oct 22, 2003·Primary Care·Jeanine Albu, Nazia Raja-Khan
Jul 21, 2004·Clinical Therapeutics·George Dailey
Oct 20, 2017·Journal of Diabetes Investigation·Wenjia YangLinong Ji
Jun 7, 2003·Drugs·Andre J Scheen
Apr 19, 2019·The Cochrane Database of Systematic Reviews·Kasper S MadsenBianca Hemmingsen
Sep 19, 2016·The Cochrane Database of Systematic Reviews·Rimke C VosGuy Ehm Rutten
Aug 22, 2003·Drugs·Ripudaman S Hundal, Silvio E Inzucchi
Aug 5, 2017·Diabetologia·Simon J GriffinGreg J Irving
Jul 17, 2018·International Journal of Endocrinology and Metabolism·Hengameh AbdiAtieh Amouzegar
Nov 17, 2020·BMC Medicine·Chu LinLinong Ji
Feb 1, 2021·Cardiovascular Diabetology·Tian LiHeng Ma