PMID: 8972550Dec 1, 1996Paper

Long-term haloperidol administration enhances and short-term administration attenuates the behavioral effects of cocaine in a place conditioning procedure

Psychopharmacology
T A KostenE J Nestler

Abstract

Many behavioral effects of cocaine are attenuated by dopamine (DA) receptor antagonists. Yet, long-term DA antagonist administration enhances neuronal responsiveness to DA in several pathways, including the mesolimbic system. This study compared the effects of short-term versus long-term administration of the DA antagonist, haloperidol, on cocaine place conditioning. In the short-term study, rats were maintained on haloperidol or vehicle for the 10 days of place conditioning. Place conditioning to moderate doses of cocaine (10-15 mg/kg) was attenuated significantly, consistent with the dopaminergic actions of haloperidol and cocaine. In the second study, rats were administered haloperidol after place conditioning which had no effect on the expression of this behavior. Finally, rats were maintained on haloperidol for 30 days prior to and throughout place conditioning and testing which resulted in significant place conditioning at low cocaine doses (2.5-7.5 mg/kg). Because these cocaine doses do not support place conditioning in vehicle-maintained rats, these data suggest that long-term haloperidol administration enhances the sensitivity to these behavioral effects in contrast to the attenuation seen with short-term haloperidol a...Continue Reading

Citations

Feb 20, 2008·Psychopharmacology·Margaret Haney, Roger Spealman
Oct 26, 2006·Behavior Genetics·Colin N HaileTherese A Kosten
May 28, 2004·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Angela Gemperle, Hans-Rudolf Olpe
Apr 4, 1998·European Journal of Pharmacology·W M Meil, M D Schechter
Jun 23, 1999·Drug Discovery Today·M P SmithA P Kozikowski
Feb 18, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Anne-Marie BédardAnne-Noël Samaha
Sep 12, 2008·Human & Experimental Toxicology·K HeardN R Zahniser
Jun 25, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Anne-Noël Samaha
Jan 4, 2001·Substance Use & Misuse·B K Boyarsky, E F McCance-Katz
Aug 30, 2008·Brain Research Bulletin·Daniela Fukue FukushiroRoberto Frussa-Filho
Mar 21, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Daniela Fukue FukushiroRoberto Frussa-Filho
Dec 10, 2013·Pharmacology, Biochemistry, and Behavior·Luis P SaitoRoberto Frussa-Filho
Dec 19, 2013·The International Journal of Neuropsychopharmacology·Eduardo A V MarinhoRoberto Frussa-Filho
Sep 6, 2019·Internal Medicine·Rino InadaSusumu Kusunoki

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