Long-term Health Outcomes in Survivors of Childhood Cancer Diagnosed Between 1990 and 2000 in a Large US Integrated Health Care System

Journal of Pediatric Hematology/oncology
Chun ChaoLisa A Mueller

Abstract

We evaluated the long-term health outcomes of childhood cancer survivors (CCS) using data from the Kaiser Permanente Southern California (KPSC) health plan, whose members have similar health care coverage. Five-year survivors of invasive cancer diagnosed at ages 0 to 18 years between 1990 and 2000 at KPSC were identified and followed to December 31, 2010. A group of KPSC members without history of cancer were 10:1 matched to each CCS for comparison. Health outcomes of interest included mortality, second cancer, and chronic comorbidities. Incidence rate ratio (IRR) was estimated using multivariable Poisson regression. Cumulative incidence of each health condition over time was calculated. A total of 652 CCS and 6520 noncancer subjects were included. Compared with the noncancer subjects, IRR was significantly elevated among CCS for mortality (IRR=14.1), second cancer (IRR=10.0), cerebrovascular disease (IRR=10.1), dyslipidemia (IRR=1.9), hearing/vision loss (IRR=5.1), heart disease (IRR=3.9), hypogonadism (IRR=4.2), renal failure (IRR=13.4), and thyroid disorder (IRR=6.4). Approximately 40% of CCS developed at least 1 chronic health condition within 15 years of cancer diagnosis. Cumulative incidence curves showed different risk t...Continue Reading

References

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Citations

Mar 10, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Chun ChaoSaro H Armenian
Apr 4, 2017·Cancer Epidemiology·Ayako HiyoshiScott Montgomery
Dec 24, 2017·European Journal of Pediatrics·Maryna Krawczuk-RybakMaria Wieczorek
Jan 10, 2019·Journal of Pediatric Psychology·Jennifer L LeeJordan Gilleland Marchak
Mar 12, 2019·The Cochrane Database of Systematic Reviews·Esmee Cm KooijmansMargreet A Veening
Mar 21, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charlotte Demoor-GoldschmidtFlorent de Vathaire
May 5, 2020·Journal of Cancer Survivorship : Research and Practice·Nina StreefkerkLeontine C M Kremer
Oct 6, 2020·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Raffaella FrancaGabriele Stocco
Mar 26, 2021·Applied Clinical Informatics·Claire BergerCharlotte Demoor-Goldschmidt
Apr 17, 2018·Toxicology and Applied Pharmacology·Amélie R Tremblay, Geraldine Delbes

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