Long-term high-fat feeding induces greater fat storage in mice lacking UCP3

American Journal of Physiology. Endocrinology and Metabolism
Sheila R CostfordMary-Ellen Harper

Abstract

Uncoupling protein-3 (UCP3) is a mitochondrial inner-membrane protein highly expressed in skeletal muscle. While UCP3's function is still unknown, it has been hypothesized to act as a fatty acid (FA) anion exporter, protecting mitochondria against lipid peroxidation and/or facilitating FA oxidation. The aim of this study was to determine the effects of long-term feeding of a 45% fat diet on whole body indicators of muscle metabolism in congenic C57BL/6 mice that were either lacking UCP3 (Ucp3(-/-)) or had a transgenically induced approximately twofold increase in UCP3 levels (UCP3tg). Mice were fed the high-fat (HF) diet for a period of either 4 or 8 mo immediately following weaning. After long-term HF feeding, UCP3tg mice weighed an average of 15% less than wild-type mice (P < 0.05) and were 20% less metabolically efficient than both wild-type and Ucp3(-/-) mice (P < 0.01). Additionally, wild-type mice had 21% lower, whereas UCP3tg mice had 36% lower, levels of adiposity compared with Ucp3(-/-) mice (P < 0.05 and P < 0.001, respectively), indicating a protective effect of UCP3 against fat gain. No differences in whole body oxygen consumption were detected following long-term HF feeding. Glucose and insulin tolerance tests reve...Continue Reading

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Citations

Apr 26, 2011·The Journal of Biological Chemistry·Ryan J MaillouxMary-Ellen Harper
Aug 5, 2009·Clinical and Experimental Pharmacology & Physiology·Iain J Clarke, Belinda A Henry
Nov 1, 2011·Molecular and Cellular Biology·Min WanMorris J Birnbaum
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Jan 22, 2013·The Journal of Biological Chemistry·Ryan J MaillouxMary-Ellen Harper
May 18, 2012·Trends in Endocrinology and Metabolism : TEM·Ryan J Mailloux, Mary-Ellen Harper
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