Long-term high-intensity sound stimulation inhibits h current (Ih ) in CA1 pyramidal neurons

The European Journal of Neuroscience
Alexandra Olimpio Siqueira CunhaR M Leão

Abstract

Afferent neurotransmission to hippocampal pyramidal cells can lead to long-term changes to their intrinsic membrane properties and affect many ion currents. One of the most plastic neuronal currents is the hyperpolarization-activated cationic current (Ih ), which changes in CA1 pyramidal cells in response to many types of physiological and pathological processes, including auditory stimulation. Recently, we demonstrated that long-term potentiation (LTP) in rat hippocampal Schaffer-CA1 synapses is depressed by high-intensity sound stimulation. Here, we investigated whether a long-term high-intensity sound stimulation could affect intrinsic membrane properties of rat CA1 pyramidal neurons. Our results showed that Ih is depressed by long-term high-intensity sound exposure (1 min of 110 dB sound, applied two times per day for 10 days). This resulted in a decreased resting membrane potential, increased membrane input resistance and time constant, and decreased action potential threshold. In addition, CA1 pyramidal neurons from sound-exposed animals fired more action potentials than neurons from control animals; however, this effect was not caused by a decreased Ih . On the other hand, a single episode (1 min) of 110 dB sound stimula...Continue Reading

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Citations

Feb 11, 2020·Frontiers in Systems Neuroscience·Michelle R Kapolowicz, Lucien T Thompson
Mar 2, 2021·Frontiers in Behavioral Neuroscience·Willian Lazarini-LopesNorberto Garcia-Cairasco

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