Long-term histological changes in the macaque primary visual cortex and the lateral geniculate nucleus after monocular deprivation produced by early restricted retinal lesions and diffuser induced form deprivation

The Journal of Comparative Neurology
Toru TakahataJon H Kaas

Abstract

Ocular dominance (OD) plasticity has been extensively studied in various mammalian species. While robust OD shifts are typically observed after monocular eyelid suture, relatively poor OD plasticity is observed for early eye removal or after tetrodotoxin (TTX) injections in mice. Hence, abnormal binocular signal interactions in the visual cortex may play a critical role in eliciting OD plasticity. Here, we examined the histochemical changes in the lateral geniculate nucleus (LGN) and the striate cortex (V1) in macaque monkeys that experienced two different monocular sensory deprivations in the same eye beginning at 3 weeks of age: restricted laser lesions in macular or peripheral retina and form deprivation induced by wearing a diffuser lens during the critical period. The monkeys were subsequently reared for 5 years under a normal visual environment. In the LGN, atrophy of neurons and a dramatic increase of GFAP expression were observed in the lesion projection zones (LPZs). In V1, although no obvious shift of the LPZ border was found, the ocular dominance columns (ODCs) for the lesioned eye shrunk and those for the intact eye expanded over the entirety of V1. This ODC size change was larger in the area outside the LPZ and in ...Continue Reading

References

Apr 26, 1977·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D H HubelS LeVay
May 6, 1977·Brain Research·D J Stelzner, E G Keating
Jun 1, 1978·The Journal of Comparative Neurology·V A CasagrandeJ K Harting
Mar 12, 1992·Nature·C D Gilbert, T N Wiesel
Jan 1, 1991·Experimental Brain Research·S J Heinen, A A Skavenski
Jan 1, 1991·Annual Review of Neuroscience·R W Oppenheim
Oct 1, 1990·The Journal of Comparative Neurology·C A Curcio, K A Allen
Mar 1, 1989·Trends in Neurosciences·M T Wong-Riley
May 20, 1983·The Journal of Comparative Neurology·K S Rockland, J S Lund
Sep 21, 1984·Science·W M CowanB B Stanfield
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M A SesmaV A Casagrande
May 1, 1980·The Journal of Comparative Neurology·S LeVayD H Hubel
Sep 1, 1993·Journal of Neuroscience Methods·Y LiuM S Cynader
May 23, 2000·Vision Research·E L Smith, L F Hung
Mar 22, 2002·Progress in Retinal and Eye Research·Ronald S HarwerthLouvenia Carter-Dawson
Aug 16, 2002·Visual Neuroscience·Kazuki MatsuuraYuzo Chino
Jun 24, 2003·Neuron·Nathaniel B SawtellMark F Bear
Nov 1, 1963·Journal of Neurophysiology·T N WIESEL, D H HUBEL
Jun 26, 2004·Annual Review of Neuroscience·Takao K Hensch
May 20, 2005·Nature·Stelios M SmirnakisNikos K Logothetis
Feb 15, 2007·The Journal of Comparative Neurology·Pedro Barroso-ChineaJosé L Lanciego
Sep 10, 2008·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Peiyan Wong, Jon H Kaas
Dec 17, 2008·Cerebral Cortex·Toru TakahataTetsuo Yamamori
Jul 8, 2009·Proceedings of the National Academy of Sciences of the United States of America·Toru TakahataTetsuo Yamamori

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