Long-term histopathologic and IVUS evaluations of a novel coiled sheet stent in porcine carotid arteries

Cardiovascular and Interventional Radiology
Hideaki KanedaPeter J Fitzgerald

Abstract

Carotid angioplasty with stent placement has been proposed as an alternative method for revascularization of carotid artery stenosis. A novel stent with a laser-cut, rolled sheet of Nitinol (EndoTex Interventional Systems, Inc., Cupertino, CA) has been developed to customize treatment of stenotic lesions in carotid arteries utilizing a single stent, designed to adapt to multiple diameters and to tapered or nontapered configurations. The purpose of this study is to evaluate the conformability and vascular response to a novel stent in a chronic porcine carotid model using serial three-dimensional intravascular ultrasound (IVUS) analysis as well as histological examination. Ten Yucatan pigs underwent stent implantation in both normal carotid arteries with adjunctive balloon angioplasty. Three-dimensional IVUS analysis was performed before stent implantation, after adjunctive balloon angioplasty, and at follow-up [1 month (n = 6), 3 months (n = 6), or 6 months (n = 8)]. Histological examination (injury score, percent plaque obstruction, and qualitative analysis) was also performed. All stents were successfully deployed and well apposed in different sized vessels (lumen area range: 19-30 mm(2)). Volumetric IVUS analysis showed no si...Continue Reading

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Citations

Jan 23, 2009·Cardiovascular and Interventional Radiology·Balázs NemesKálmán Hüttl
Apr 22, 2009·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Hasan JilaihawiJean-Claude Laborde
Apr 10, 2014·Japanese Journal of Radiology·Hisayuki ChoYukio Miki
May 23, 2012·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Ameer E HassanAdnan I Qureshi
Sep 10, 2010·Journal of the American College of Cardiology·Scot Garg, Patrick W Serruys
Feb 6, 2010·AJNR. American Journal of Neuroradiology·H ZacharatosA I Qureshi

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