Long-term immunogenicity and safety of inactivated Hantaan virus vaccine (Hantavax™) in healthy adults

Vaccine
Joon Young SongWoo Joo Kim

Abstract

Hemorrhagic fever with renal syndrome is a serious health problem in Eurasian countries, including Korea and China. This study evaluated the long-term immunogenicity and safety of formalin-inactivated Hantaan virus vaccine (Hantavax™). A phase III, multi-center clinical trial was undertaken to evaluate the immunogenicity and safety of Hantavax™ (three-dose schedule at 0, 1, and 13 months) among healthy adults. Immune response was assessed using the plaque reduction neutralizing antibody test (PRNT) and immunofluorescent antibody assay (IFA). Antibody levels were measured pre-vaccination and at 2, 13, 14, 25, 37, and 49 months after the initial vaccination. Systemic and local adverse events were assessed. A total of 226 healthy subjects aged 19-75 years were enrolled. Following two primary doses of Hantavax™, the seroconversion rate was 90.14% by IFA, but it was only 23.24% by PRNT50. With booster administration, seropositive rates were 87.32% and 45.07% at one month post-vaccination according to IFA and PRNT50, respectively. In young adults (19-39 years), the seropositive rate according to PRNT50 reached about 60% after booster vaccination. The mean duration of seropositive response was 735 days for PRNT50 and 845 days for IFA....Continue Reading

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Citations

Jan 27, 2018·The Journal of Infectious Diseases·Jaehun JungKyungmin Huh
Mar 21, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Won-Keun KimJin-Won Song
Sep 8, 2020·Clinical and Experimental Pharmacology & Physiology·Naveed MunirAneezah Sana
Feb 23, 2020·Frontiers in Microbiology·Rongrong LiuXingan Wu
Jan 10, 2017·Frontiers in Cellular and Infection Microbiology·Lin-Feng ChengFang-Lin Zhang
Aug 28, 2020·Frontiers in Bioengineering and Biotechnology·Michael Hilary D'Souza, Trushar R Patel
Nov 2, 2019·Infection & chemotherapy·Ji Yun NohJin Won Song
Jul 7, 2019·Viruses·Rebecca L Brocato, Jay W Hooper
Jul 17, 2020·MSphere·Taylor B Engdahl, James E Crowe
Dec 8, 2020·Indian Journal of Pharmacology·Harvinder SinghBikash Medhi
Nov 5, 2020·Current Treatment Options in Infectious Diseases·Kalpa DheerasekaraRohitha Muthugala
Jun 3, 2021·Vaccines·Joon-Yong BaeMan-Seong Park

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