PMID: 8611360Feb 1, 1996Paper

Long-term immunosuppressive treatment of a child with Takayasu's arteritis and high IgE immunoglobulins

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
M G BrunetteG Barrette

Abstract

A 7-year-old child presented with a severe form of Takayasu's arteritis, with two consecutive episodes involving the right testis and then the left kidney 6 months later. The renal artery obstruction was accompanied by severe hypertension. An aortography showed a complete obstruction of the left renal artery and a narrowing of the right subclavian artery. Plasma renin activity was high. Serum immunoglobulins were within the normal range, except for an increase in IgE (880 mu/l). Despite 4 months', treatment with antihypertensive drugs, prednisone, cyclophosphamide, and anticoagulant, the blood pressure never returned to normal and the left renal function remained completely absent. A nephrectomy was performed which immediately normalized plasma renin activity and blood pressure. The child was subsequently treated with alternate-day prednisone for 3 months, alternating with 3 months of cyclophosphamide or, later, azathioprine. Persantine (dipyridamole) and acetylsalicylic acid were administered continuously. The right radial pulse returned to normal within 2 years. An 8-year follow-up failed to detect any new episode of arteritis. The right kidney showed signs of compensatory hypertrophy. Finally, a recent arteriography demonstr...Continue Reading

References

Jan 1, 1991·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·L S MilnerS E Levin
Mar 1, 1985·Medicine·S HallG G Hunder
Jul 1, 1985·Annals of Internal Medicine·J H ShelhamerA S Fauci
Jun 20, 1986·Medizinische Klinik·C Müller-SchwefeG Hoppe-Seyler
Jun 1, 1994·Annals of Internal Medicine·G S KerrG S Hoffman
Aug 1, 1993·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·I RobertiJ Churg

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Citations

Sep 30, 2008·Pediatric Rheumatology Online Journal·Safia Al AbrawiRolando Cimaz
Oct 8, 2013·Rheumatology·Gokhan KeserKenan Aksu
Feb 27, 2010·Allergology International : Official Journal of the Japanese Society of Allergology·Elke O LugerAndreas Radbruch
Sep 16, 2006·Nature Reviews. Immunology·Andreas RadbruchFalk Hiepe
Mar 28, 2019·Frontiers in Immunology·Faruk RamadaniDavid J Fear

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