Long-term impacts of tonsillectomy on children's immune functions

Journal of Family Medicine and Primary Care
Masoud RadmanPooneh Jalali

Abstract

There exist a wide level of discrepancy regarding the role of tonsils and its indication among pediatricians and ENT specialists. This fact sometimes causes confusion and delay in making the right decisions by parents and specialists for appropriate treatment of patients. Thus, the aim of this study was to investigate the effects of long-term tonsillectomy on the immune system of patients. In this case-control study we measured the status of immune system in 34 children (aged 9-15 years) following 4 to 6 years of tonsillectomy. We have also enrolled 30 healthy children with similar age group. Venous blood samples were taken and the serum levels of IgG, IgA, and IgM were detected along with expression of CD4, CD8, CD10 and CD56. Data were analyzed by SPSS version 18 software and a P < 0.05 was considered as significant. We found that the mean serum levels IgM, IgA, and IgG in the case group was significantly (P < 0.0001) lower than the control group. Whereby, the CD4, CD8 and CD56 expressions was examined, there was no significant difference in both groups while only CD10 expression was lower in tonssiloctomized patients (P = 0.108). Overall, according to these findings, CD10 as a marker of B lymphocytes in children undergoing t...Continue Reading

References

Oct 1, 1992·Clinical Otolaryngology and Allied Sciences·M SainzM Ciges
Nov 22, 2002·International Journal of Pediatric Otorhinolaryngology·Aykut IkincioğullariEmel Babacan
Apr 24, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Juan Carlos Andreu-BallesterCarlos Peñarroja Otero
Jan 20, 2009·International Journal of Pediatric Otorhinolaryngology·Irfan KaygusuzNesrin Demir
Nov 20, 2012·International Journal of Pediatric Otorhinolaryngology·Rajeev SubramanyamSenthilkumar Sadhasivam
Jan 26, 2013·Nature Reviews. Immunology·Andrea CeruttiIrene Puga
Mar 19, 2013·Brazilian Journal of Otorhinolaryngology·Fábio Pires SantosShirley Shizue Nagata Pignatari
Feb 19, 2014·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Ilaria BrambillaGian Luigi Marseglia
Apr 8, 2014·Biogerontology·Neil A MabbottDavid S Donaldson
Jul 22, 2014·Scandinavian Journal of Immunology·G Pidelaserra MartíK A Brokstad
Feb 24, 2015·Nature Reviews. Immunology·Stephen L NuttLynn M Corcoran
Jun 10, 2015·International Journal of Pediatric Otorhinolaryngology·Mohamad A BitarMarc Mourad
Jan 13, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Jochen P WindfuhrReinhard Berner
Jun 25, 2016·Pediatrics International : Official Journal of the Japan Pediatric Society·Yukihiko KawasakiMitsuaki Hosoya
Jun 28, 2016·Journal of Autoimmunity·Jianguang JiKristina Sundquist
Aug 9, 2016·International Journal of Pediatric Otorhinolaryngology·David KasleJeffrey Cheng
Aug 17, 2018·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Yin RenKonstantina M Stankovic

❮ Previous
Next ❯

Citations

Aug 26, 2021·World Journal of Otorhinolaryngology - Head and Neck Surgery·Alexandra ArambulaLaura Neff

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
flow cytometry

Software Mentioned

FlowMax

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Bangladesh Medical Research Council Bulletin
M NasrinK L Saha
Deutsche medizinische Wochenschrift
W Lutz
Vestnik otorinolaringologii
I I SHCHERBATOV
Revista chilena de pediatría
J BARROILHET
© 2022 Meta ULC. All rights reserved