PMID: 6109898Jan 31, 1981Paper

Long-term impairment of suppressor-cell function by cyclophosphamide in minimal-change nephropathy and its association with therapeutic response

Lancet
D TaubeD G Williams

Abstract

Lymphocyte suppressor-cell function was studied by induction with concanavalin A in 31 patients with minimal-change nephropathy (MCN) in remission. 21 patients had been treated with cyclophosphamide 0.5--12.0 years previously (mean 6.5 years) and had been in remission for 0.5--9.0 years (mean 5.1 years). The remaining 10 patients had never received cyclophosphamide and had been in remission for 1--10 years (mean 5.3 years). The cyclophosphamide-treated group had significantly less suppressor-cell function than either the controls or the non-cyclophosphamide-treated group, the latter being not significantly different from normal. When patients who had received cyclophosphamide were divided into those who had relapsed after taking this drug (10 patients) and those who had not (11 patients), suppressor-cell function was significantly impaired in the non-relapsing group. This association of impaired suppressor-cell function with failure to relapse may indicate that suppressor cells have a pathogenetic role in MCN and that the therapeutic effect of cyclophosphamide in this disease is to diminish their function. Alternatively, the impaired suppressor-cell function in the non-relapsing group may be simply a marker of effective treatme...Continue Reading

References

May 1, 1977·The Journal of Experimental Medicine·S Dorsch, R Roser
Feb 23, 1980·British Medical Journal·G A McLoughlinN Kirkham
Jan 1, 1980·Kidney International·R S TrompeterJ F Soothill

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Citations

Jan 1, 1989·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·H W Schnaper
Dec 31, 2003·Transplantation Proceedings·C I JanY F Lin
Feb 16, 1985·Lancet·R S TrompeterJ S Cameron
Feb 16, 1984·The New England Journal of Medicine·J FeehallyR J Postlethwaite
Nov 1, 1981·Journal of Clinical Pathology·D G Williams
Nov 1, 1982·Scandinavian Journal of Immunology·L B AstrupA Svejgaard
Jul 1, 1987·Acta paediatrica Scandinavica·T Linné, J Wasserman
Mar 1, 1982·Clinical Immunology and Immunopathology·M J Wu, A V Moorthy
Jun 23, 2011·Clinical and Experimental Nephrology·Yukihiko Kawasaki
Jan 1, 1989·Acta Neurologica Scandinavica·B M UitdehaagO R Hommes

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