PMID: 11340601May 8, 2001Paper

Long-term implantation test and tumorigenicity of polyvinyl alcohol hydrogel plates

Journal of Biomedical Materials Research
T NakamuraY Shimizu

Abstract

Two types of flat plates made from a polyvinyl alcohol (PVA) hydrogel with a water content of 80 and 20 (PVA-H80, PVA-H20), 20 x 10 x 1 mm in size, were subcutaneously implanted into each of 50 young, male Wistar rats. As a control, a sham operation was done on another set of 50 rats (Sham Op group). The shape and transparency of the PVA hydrogel were unchanged for up to 24 months. Tumors arose in 14 rats from the PVA-H80 group. In the PVA-H20 group, tumors appeared in 15 rats. The average tumor latency was 598 +/- 109 days in the PVA-H80 and 637 +/- 94 days in the PVA-H20. There was no difference in tumor incidence between the PVA-H20 and PVA-H80 groups (p < 0.05). In the Sham Op group, no malignant tumors appeared. Histopathologically, the tumors induced by hydrogel plates were malignant tumors resembling fibrosarcoma or malignant fibrous histiocytoma. This indicates that PVA hydrogel implants also induce solid state carcinogenesis at a similarly high rate to medical grade hydrophobic material reported in a previous study.

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Citations

Apr 20, 2012·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Maribel I BakerBarbara D Boyan
Dec 18, 2004·Biomaterials·Masanori KobayashiMasanori Oka
Nov 29, 2015·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Atsushi Suzuki, Saori Sasaki
Feb 6, 2004·Journal of Biomedical Materials Research. Part a·Lino FerreiraJonathan S Dordick
Apr 5, 2019·Advanced Healthcare Materials·Teppei ArakiTsuyoshi Sekitani

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