Long-term in vitro study of paclitaxel-eluting bioresorbable core/shell fiber structures

Journal of Controlled Release : Official Journal of the Controlled Release Society
Amir KraitzerMeital Zilberman

Abstract

Paclitaxel-eluting bioresorbable core/shell fiber structures for stent applications and local cancer treatment were developed and studied. These structures were composed of a polyglyconate core and a porous PDLGA shell loaded with the anti-proliferative agent paclitaxel, prepared using freeze drying of inverted emulsions. The investigation of these new composite fibers focused on the effects of the emulsion's composition (formulation) and process kinetics on the long-term drug release from the fibers, in light of the shell's morphology and degradation profile. Paclitaxel release from the porous shell was relatively slow due to its extremely hydrophobic nature. It exhibited three phases of release, which corresponded to the degradation profile of the host PDLGA. We found that the effect of the emulsion formulation on the release profile is more significant than the effect of the process kinetics. The copolymer composition had the most dominant effect on the drug release profile from the composite fibers. The polymer content also affected the release profile, whereas the drug content and the organic:aqueous phase ratio resulted in minor effects. Emulsions with a less hydrophobic nature are favorable for effective controlled relea...Continue Reading

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Citations

Jul 13, 2006·Annual Review of Biomedical Engineering·Meital Zilberman, Robert C Eberhart
Jan 25, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·James J KleinedlerTammy R Dugas
Aug 5, 2009·Advanced Drug Delivery Reviews·Syandan ChakrabortyKam W Leong
Jun 6, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Amir KraitzerMeital Zilberman
Oct 16, 2012·Journal of Biomedical Materials Research. Part a·Amir KraitzerMeital Zilberman
May 3, 2016·Journal of the Mechanical Behavior of Biomedical Materials·Farrokh SharifiNastaran Hashemi
Jul 20, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Farhad RikhtegarVartan Kurtcuoglu
Nov 18, 2017·Macromolecular Bioscience·Marilyn C McNamaraNicole N Hashemi
May 16, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Zeynep R EgeOguzhan Gunduz

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