Long-term in vivo electromechanical reshaping for auricular reconstruction in the New Zealand white rabbit model

The Laryngoscope
Karam BadranBrian J F Wong

Abstract

To demonstrate the dosimetry effect of electromechanical reshaping (EMR) on cartilage shape change, structural integrity, cellular viability, and remodeling of grafts in an in vivo long-term animal model. Animal study. A subperichondrial cartilaginous defect was created within the base of the pinna of 31 New Zealand white rabbits. Autologous costal cartilage grafts were electromechanically reshaped to resemble the rabbit auricular base framework and mechanically secured into the pinna base defect. Forty-nine costal cartilage specimens (four control and 45 experimental) successfully underwent EMR using a paired set of voltage-time combinations and survived for 6 or 12 weeks. Shape change was measured, and specimens were analyzed using digital imaging, tissue histology, and confocal microscopy with LIVE-DEAD viability assays. Shape change was proportional to charge transfer in all experimental specimens (P < .01) and increased with voltage. All experimental specimens contoured to the auricular base. Focal cartilage degeneration and fibrosis was observed where needle electrodes were inserted, ranging from 2.2 to 3.9 mm. The response to injury increased with increasing charge transfer and survival duration. EMR results in appropria...Continue Reading

References

Aug 1, 1993·Plastic and Reconstructive Surgery·S Nagata
Aug 1, 1997·Journal of Biomechanics·V N BagratashviliS M Howdle
Apr 29, 1998·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·F Firmin
Aug 9, 2002·Archives of Facial Plastic Surgery·Yuri OvchinnikovAlexander Sviridov
Jan 1, 1959·Plastic and Reconstructive Surgery and the Transplantation Bulletin·R C TANZER
Nov 7, 2003·The Laryngoscope·Ki-Hong Kevin HoBrian J F Wong
Apr 15, 2004·Lasers in Surgery and Medicine·Serge MordonColette Creusy
Feb 2, 2006·Annals of Biomedical Engineering·Dmitriy E ProtsenkoBrian J F Wong
Mar 22, 2006·Archives of Facial Plastic Surgery·Amir M KaramBrian J F Wong
Sep 18, 2008·Lasers in Surgery and Medicine·Yongseok ChaeBrian J F Wong
Apr 10, 2009·Forensic Science International : Synergy·Chiarella SforzaVirgilio F Ferrario
Jul 9, 2010·Annals of Biomedical Engineering·Cyrus T ManuelBrian J F Wong
Sep 16, 2010·Annals of Biomedical Engineering·Dmitry E ProtsenkoBrian J F Wong
May 25, 2011·IEEE Transactions on Bio-medical Engineering·Edward C WuBrian J F Wong
Oct 26, 2011·The Laryngoscope·Cyrus T ManuelBrian J F Wong
Jul 11, 2012·Arthritis and Rheumatism·Dongrim SeolJames A Martin
Dec 18, 2013·JAMA Facial Plastic Surgery·Allen FouladBrian J Wong
Feb 4, 2014·Facial Plastic Surgery : FPS·Karam W BadranBrian J F Wong

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Citations

Apr 10, 2016·Angewandte Chemie·Bryan M HunterMichael G Hill
May 28, 2019·Lasers in Surgery and Medicine·Allison C HuBrian J F Wong
Jan 21, 2020·Clinical Biomechanics·Tony D NguyenBrian J F Wong
Mar 15, 2020·Journal of Dermatological Science·Tiffany T PhamBrian J F Wong
Mar 6, 2021·The Laryngoscope·Ellen M HongBrian J F Wong

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