PMID: 8609453Feb 1, 1996Paper

Long-term in vivo transmission of alpha-particle-induced chromosomal instability in murine haemopoietic cells

International Journal of Radiation Biology
G E WatsonEric G Wright

Abstract

We have previously reported non-clonal cytogenetic aberrations in the clonal descendants of murine haemopoietic stem cells irradiated in vitro with alpha-particles. The data are consistent with a transmissible chromosomal instability induced in a stem cell resulting in a diversity of aberrations in its clonal progeny many cell divisions later. To determine whether this instability is transmissible in vivo, bone marrow cells obtained from the male mouse have been irradiated with alpha-particles in vitro and transplanted into female recipients. In the repopulated haemopoietic system we have observed persisting chromosomal instability up to 1 year post-transplantation. The findings demonstrate a long-lived effect of the alpha-particle-induced lesion in the donor repopulating stem cells.

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Citations

Apr 4, 2013·International Journal of Environmental Research and Public Health·Kanokporn Noy RithidechElbert Whorton
Sep 24, 2005·The British Journal of Radiology·P Uma Devi, M Satyamitra
Aug 1, 1997·International Journal of Radiation Biology·S D BoufflerD Papworth
Jan 9, 1999·International Journal of Radiation Biology·S SalomaaB Lambert
Dec 7, 2007·International Journal of Radiation Biology·Eric G Wright
Dec 13, 2005·Hematological Oncology·Eric G Wright
Mar 17, 2012·Dose-response : a Publication of International Hormesis Society·Kanokporn Noy RithidechElbert B Whorton
Jun 23, 2016·Radiation Research·A C HeuskinS V Costes
Jul 11, 2003·Health Physics·John D BoiceMarilyn Stovall
Jul 24, 2003·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·John B Little
Nov 21, 2013·The Journal of Pathology·Debayan MukherjeeEric G Wright
Jun 21, 2003·Radiation Research·Elizaveta NeronovaAlexey Nikiforov
Jul 1, 1997·International Journal of Radiation Biology·M PlumbE Wright
Feb 26, 2000·Carcinogenesis·J B Little
Oct 5, 2006·Journal of Radiation Research·A T Natarajan
Mar 11, 2011·Radiation Research·Nikolay A ZyuzikovEric G Wright
May 1, 1997·International Journal of Radiation Biology·G E WatsonE G Wright
Oct 9, 2003·Annals of the ICRP·Roger Cox, Christian Streffer
Jul 11, 2003·Health Physics·Leslie E SmithWilliam F Morgan

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