Long-term influence of adjuvant breast radiotherapy on cognitive function in breast cancer patients treated with conservation therapy

International Journal of Clinical Oncology
Osamu ShibayamaYosuke Uchitomi

Abstract

The mechanisms underlying cognitive decline after radiotherapy not directed at brain areas remains unclear. We previously suggested that adjuvant breast radiotherapy in breast conservation therapy could lower memory function soon after therapy, and that the process might be partially mediated by plasma interleukin (IL)-6 levels. The present study investigated how that relationship changes longitudinally. We performed the Wechsler Memory Scale-Revised (WMS-R) test and measured plasma IL-6 levels for 47 breast cancer surgical patients within 1 year after the initial therapy (study 1) and more than 2 years after study 1 (study 2). We also performed 2 × 2 mixed [the radiotherapy group (n = 25) or the no-radiotherapy group (n = 22) × study 1 or study 2] analysis of covariance on the WMS-R indices and plasma IL-6 levels. The association between changes in plasma IL-6 levels and changes in the WMS-R indices between the two studies was evaluated using Pearson's correlation coefficient. The Immediate Verbal Memory Index was significantly higher in study 2. The Delayed Recall Index was significantly higher in study 2 and significantly lower in the radiotherapy group only in study 1. There was a significant correlation between changes in ...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Apr 6, 1999·Archives of Neurology·R C PetersenE Kokmen
Oct 13, 2001·International Journal of Radiation Oncology, Biology, Physics·H GeinitzM Molls
Mar 28, 2002·Seminars in Radiation Oncology·Yuhchyau ChenPaul Okunieff
Oct 20, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nathan L SparkmanRodney W Johnson
Apr 17, 2008·Neuropsychology Review·Jeffrey S WefelChristina A Meyers
Jul 17, 2008·Breast Cancer Research and Treatment·Catherine QuesnelHans Ivers
Feb 19, 2009·Cancer·Heather S L JimPaul B Jacobsen
Nov 3, 2009·International Journal of Radiation Oncology, Biology, Physics·Virginie MarchandStéphane Supiot
Nov 10, 2009·Lancet·Carole SoussainJean-Yves Delattre
Jan 2, 2010·Brain and Cognition·Karren H M ChenMichael W L Chee
May 19, 2010·Journal of Cancer Research and Therapeutics·M G JanakiA G Rajeev
Mar 1, 2007·Journal of Oncology Practice·Sadhna KohliGary R Morrow
Oct 5, 2010·International Journal of Radiation Oncology, Biology, Physics·Sabine NoalFlorence Joly
Jul 21, 2011·Neuropsychology Review·Alberto CostaGiovanni Augusto Carlesimo
Jun 6, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Brenna C McDonaldAndrew J Saykin
Sep 26, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tim A AhlesElizabeth L Ryan
Jul 10, 2014·Breast Cancer Research and Treatment·Ying ZhengQi Dai
Jul 16, 2014·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Kenji SekiguchiHirofumi Mukai
Jan 6, 2018·The Lancet Oncology·Brian M AlexanderUNKNOWN Response Assessment in Neuro-Oncology (RANO) group

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.