Long-term interaction between microglial cells and cochlear nucleus neurons after bilateral cochlear ablation

The Journal of Comparative Neurology
Verónica Fuentes-SantamariaJosé Manuel Juiz

Abstract

The removal of afferent activity has been reported to modify neuronal activity in the cochlear nucleus of adult rats. After cell damage, microglial cells are rapidly activated, initiating a series of cellular responses that influences neuronal function and survival. To investigate how this glial response occurs and how it might influence injured neurons, bilateral cochlear ablations were performed on adult rats to examine the short-term (16 and 24 hours and 4 and 7 days) and long-term (15, 30, and 100 days) changes in the distribution and morphology of microglial cells (immunostained with the ionized calcium-binding adaptor molecule 1; Iba-1) and the interaction of microglial cells with deafferented neurons in the ventral cochlear nucleus. A significant increase in the mean cross-sectional area and Iba-1 immunostaining of microglial cells in the cochlear nucleus was observed at all survival times after the ablation compared with control animals. These increases were concomitant with an increase in the area of Iba-1 immunostaining at 24 hours and 4, 7, and 15 days postablation. Additionally, microglial cells were frequently seen apposing the cell bodies and dendrites of auditory neurons at 7, 15, and 30 days postablation. In sum...Continue Reading

References

Nov 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T MoriokaW J Streit
Aug 8, 1994·The Journal of Comparative Neurology·D I Lurie, E W Rubel
Feb 3, 1997·The Journal of Comparative Neurology·A CaicedoJ L Puel
Jun 19, 1998·Brain Research. Molecular Brain Research·D ItoS Kohsaka
Sep 24, 1999·Journal of Neuroscience Research·A J Bruce-Keller
Nov 24, 1999·Canadian Journal of Physiology and Pharmacology·A AraqueP G Haydon
Dec 3, 1999·The Journal of Comparative Neurology·C R Förster, R B Illing
Feb 11, 2000·Toxicologic Pathology·W J Streit
Aug 2, 2001·Journal of Biochemistry·K Nakajima, S Kohsaka
Aug 14, 2001·Biochemical and Biophysical Research Communications·Y SasakiY Imai
Jul 26, 2002·Investigative Radiology·Christoph U HerbornStefan G Ruehm
Oct 19, 2002·Science·R Douglas Fields, Beth Stevens-Graham
Nov 14, 2002·Experimental Neurology·S M MulyS J Potashner
Apr 30, 2003·The Journal of Comparative Neurology·Verónica Fuentes-SantamariaCraig K Henkel
Feb 3, 2004·The Journal of Comparative Neurology·Juan Carlos AlvaradoJudy K Brunso-Bechtold
Feb 6, 2004·Journal of Neurochemistry·Keiko OhsawaShinichi Kohsaka
Jan 11, 2005·Neurobiology of Aging·Robert E Mrak, W Sue T Griffin
Feb 9, 2005·The Journal of Comparative Neurology·Verónica Fuentes-SantamariaCraig K Henkel
Jan 24, 2006·Journal of Neuroscience Research·Masato FujiokaHideyuki Okano
Feb 1, 2006·Journal of Physiology, Paris·Keith J ToddRichard Robitaille
May 17, 2007·Current Medicinal Chemistry·S Thameem DheenEng-Ang Ling
May 19, 2007·Brain Research Reviews·Staffan Cullheim, Sebastian Thams
Oct 30, 2007·Nature Neuroscience·Uwe-Karsten Hanisch, Helmut Kettenmann

❮ Previous
Next ❯

Citations

Dec 3, 2013·Hearing Research·Donald A GodfreyMatthew A Godfrey
Jul 30, 2016·Frontiers in Cellular Neuroscience·Bryce D GrierClaire E J Cheetham
Dec 14, 2017·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Joan S BaizerSandra F Witelson
Mar 16, 2019·Frontiers in Neuroscience·Juan Carlos AlvaradoJosé M Juiz
Mar 19, 2019·Frontiers in Cellular Neuroscience·Veronica Fuentes-SantamaríaIsabel Varela-Nieto
Jan 8, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Arianna Di StadioEvanthia Bernitsas
Dec 6, 2020·The European Journal of Neuroscience·Samuel David Webb, Llwyd David Orton

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.