Long-Term Isolation Elicits Depression and Anxiety-Related Behaviors by Reducing Oxytocin-Induced GABAergic Transmission in Central Amygdala

Frontiers in Molecular Neuroscience
Rafael T HanHeung S Na

Abstract

Isolation stress is a major risk factor for neuropsychiatric disorders such as depressive and anxiety disorders. However, the molecular mechanisms underlying isolation-induced neuropsychiatric disorders remain elusive. In the present study, we investigated the subcellular mechanisms by which long-term isolation elicits depression and anxiety-related behaviors in mice. First, we found that long-term isolation induced depression-related behaviors in the forced swimming test (FST) and the sucrose preference test, as well as anxiety-related behaviors in the elevated zero maze test (EZMT) and the open field test. Next, we showed that intracentral amygdala (CeA) injection of oxytocin (OXT), but not intracerebroventricular injection, attenuated isolation-induced depression and anxiety-related behaviors via oxytocin receptor (OXTR), not vasopressin-1a receptor (V1aR), in the FST and EZMT, respectively. Quantitative real-time polymerase chain reaction analysis revealed that after 5 weeks of isolation, mRNA transcription of OXTR in the CeA, but not that of V1aR, significantly decreased, whereas OXT and vasopressin mRNA transcription in the paraventricular nucleus of hypothalamus did not change significantly. Whole-cell patch clamping of ...Continue Reading

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Citations

Feb 21, 2019·Journal of Neuroendocrinology·Tatsushi Onaka, Yuki Takayanagi
Dec 4, 2019·Epilepsy Currents·Lola Lozano, Catherine A Christian
Feb 29, 2020·Journal of Psychopharmacology·Thatiane De Oliveira SergioHélio Zangrossi
Oct 7, 2020·Proceedings of the National Academy of Sciences of the United States of America·Natalia Duque-WilckensBrian C Trainor
Feb 20, 2021·Neuropeptides·Priti Ramakant Gupta, Kedar Prabhavalkar
Jul 25, 2021·International Journal of Molecular Sciences·Hsin-Ju ChuangMing-Yi Chou
Oct 7, 2021·International Journal of Clinical Practice·Zahra Taheri ZadehKhadijeh Esmaeilpour
Oct 30, 2021·Journal of Neuroendocrinology·Tatsushi Onaka, Yuki Takayanagi
Apr 6, 2021·British Journal of Pharmacology·Mariana RaeLakshmi A Devi

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Datasets Mentioned

BETA
GU214026.1

Methods Mentioned

BETA
biopsies
PCR

Software Mentioned

Mini Analysis
pClamp

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