PMID: 2505284Jan 1, 1989Paper

Long-term lithium treatment in rats attenuates m-chlorophenylpiperazine-induced decreases in food intake but not locomotor activity

Psychopharmacology
C S AulakhD L Murphy

Abstract

Administration of various doses of m-chlorophenylpiperazine (m-CPP, a 5-HT agonist) to rats produced dose-related decreases in food intake and locomotor activity. Long-term (21-25 days) but not short-term (3-7 days) lithium treatment attenuated m-CPP-induced decreases in food intake. However, neither short-term nor long-term lithium treatment had any significant effect on m-CPP-induced decreases in locomotor activity. These findings suggest development of functional subsensitivity of 5-HT1B receptors mediating decreases in food intake and provide further evidence that m-CPP's effects on food intake are mediated by different mechanisms from those regulating locomotor activity.

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Citations

Dec 1, 1991·Biological Psychiatry·R S Kahn, S Wetzler
Nov 1, 1994·Pharmacology, Biochemistry, and Behavior·C S AulakhD L Murphy
Apr 1, 1994·Pharmacology, Biochemistry, and Behavior·C S AulakhD L Murphy
Mar 25, 1998·Pharmacology, Biochemistry, and Behavior·G J KantS Ghosh
Nov 1, 1990·Neuropharmacology·G SchreiberD L Murphy

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