Long-term low-level ambient air pollution exposure and risk of lung cancer - A pooled analysis of 7 European cohorts.

Environment International
Ulla Arthur HvidtfeldtDaniela Fecht

Abstract

Ambient air pollution has been associated with lung cancer, but the shape of the exposure-response function - especially at low exposure levels - is not well described. The aim of this study was to address the relationship between long-term low-level air pollution exposure and lung cancer incidence. The "Effects of Low-level Air Pollution: a Study in Europe" (ELAPSE) collaboration pools seven cohorts from across Europe. We developed hybrid models combining air pollution monitoring, land use data, satellite observations, and dispersion model estimates for nitrogen dioxide (NO2), fine particulate matter (PM2.5), black carbon (BC), and ozone (O3) to assign exposure to cohort participants' residential addresses in 100 m by 100 m grids. We applied stratified Cox proportional hazards models, adjusting for potential confounders (age, sex, calendar year, marital status, smoking, body mass index, employment status, and neighborhood-level socio-economic status). We fitted linear models, linear models in subsets, Shape-Constrained Health Impact Functions (SCHIF), and natural cubic spline models to assess the shape of the association between air pollution and lung cancer at concentrations below existing standards and guidelines. The analys...Continue Reading

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Citations

Dec 6, 2020·Environmental Research·Ulla Arthur HvidtfeldtOle Raaschou-Nielsen
Jul 16, 2021·Environmental Research·Si-Tian ZangYu-Hong Zhao
Aug 10, 2021·Investigative Ophthalmology & Visual Science·Alyssa GrantEllen E Freeman
Jul 20, 2021·International Journal of Cancer. Journal International Du Cancer·Rina SoZorana J Andersen

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