Long-Term Magnetization Transfer Ratio Evolution in Multiple Sclerosis White Matter Lesions

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
Yufan ZhengElizabeth Fisher

Abstract

Magnetization transfer ratio (MTR), a magnetic resonance imaging technique used to assess tissue integrity, correlates with demyelination and axonal loss in multiple sclerosis (MS) lesions. In acute white matter lesions, short-term MTR changes mainly reflect demyelination and remyelination, in addition to edema and axonal and glial changes. Long-term MTR changes in MS lesions have not been studied extensively. A new quantitative image analysis method was developed to measure long-term MTR changes in MS lesions. The method was applied to a group of 59 patients and 14 healthy control subjects followed for 4 years. MTR changes in white matter lesions were analyzed, where lesion voxels were classified into six categories based on starting MTR and change over time. For each patient, the proportion of lesion voxels in each MTR-change category was calculated. Correlations between long-term MTR evolution, disability progression, and brain atrophy were investigated. The proportion of lesion voxels in the high stable category correlated with less atrophy progression, while the proportion with low and increasing MTR correlated with increased atrophy. The proportion of lesion voxels in the high and stable MTR lesion category was significan...Continue Reading

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Citations

Apr 21, 2018·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Francesca BagnatoRichard Dortch
Sep 11, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Peter van Gelderen, Jeff H Duyn
Apr 6, 2019·Current Opinion in Neurology·Chenyu Tim WangYael Barnett
Nov 21, 2021·Clinical and Translational Science·Kawita M S KanhaiGeert Jan Groeneveld

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