PMID: 9537038Jan 1, 1980Paper

Long-term maintenance of HLA-D restricted T cells specific for soluble antigens

Scandinavian Journal of Immunology
J T KurnickH Wigzell

Abstract

Lymphocytes from donors sensitized to soluble protein antigens tuberculin (PPD) and tetanus toxoid were stimulated in vitro with these antigens. The blasts were isolated on density gradients and maintained in long-term proliferating culture by the addition of supernatants from phytohaemagglutinin-stimulated (PHA) cultures. Blasts can be shown to retain specificity for the original stimulating antigen as measured by stimulation of DNA synthesis, but only when the antigen is presented in the company of a cooperating cell population. Autologous irradiated peripheral blood lymphocytes provide the best cooperation, but donors who share HLA-D antigens will also allow for continued proliferation in the presence of the appropriate soluble antigen. Donors sharing at HLA-A, -B, or -C show minimal ability to cooperate. The soluble antigen-specific blast cells do not manifest alloreactivity. The data are discussed with regard to possible application to clinical histocompatibility typing and to the implications of selfrecognition in the immune response.

References

May 1, 1978·Tissue Antigens·E Möller, B Lindblom
May 1, 1976·The Journal of Experimental Medicine·L ShouR A Good
Jul 14, 1977·Nature·S Gillis, K A Smith
Jul 1, 1978·European Journal of Immunology·G S HansenA Svejgaard
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Oct 1, 1978·The Journal of Experimental Medicine·F B MudawwarR S Geha
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Jan 1, 1968·Scandinavian Journal of Clinical and Laboratory Investigation·C E Mogensen

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Citations

Jul 1, 1981·Journal of Clinical Immunology·J B BurnsR P Lisak
Feb 1, 1992·Medical Hypotheses·B Daunter
Mar 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·B SredniA S Fauci
Aug 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·E T ChuR S Geha
May 1, 1986·The Journal of Clinical Investigation·A DurandyC Griscelli
Dec 1, 1984·Immunobiology·C R WagnerD R Burger
May 1, 1981·Medical Hypotheses·B Daunter, E V Mackay
Oct 1, 1983·Scandinavian Journal of Immunology·E QvigstadE Thorsby
Jan 1, 1988·Scandinavian Journal of Immunology·K LundinH Wigzell
Oct 1, 1981·Tissue Antigens·S Bright, A J Munro
Jun 1, 1981·Immunology Today·A R Hayward
Apr 15, 1983·Cellular Immunology·J BurnsR P Lisak
Jan 1, 1982·Immunological Reviews·E ThorsbyH Nousiainen
Mar 1, 1985·Scandinavian Journal of Immunology·E QvigstadH Hirschberg
Dec 1, 1982·Scandinavian Journal of Immunology·E J Berle, E Thorsby
Feb 1, 1983·Scandinavian Journal of Immunology·P Altevogt, H Wigzell
Nov 1, 1989·Arthritis and Rheumatism·R M PopeB V Desai
Jun 1, 1984·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section C, Immunology·E Qvigstad, H Hirschberg
Nov 1, 1982·Scandinavian Journal of Immunology·D Haar, I Heron

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