Long-term management of depression

The American Journal of Medicine
R M Hirschfeld, A F Schatzberg

Abstract

Major depression is often a chronic and recurrent disorder. Findings from a landmark study, the Pittsburgh Study of Maintenance Therapies in Recurrent Depression, demonstrate that full doses of antidepressants prevent recurrent depression and that maintenance therapy lasting at least 5 years may be required for patients with severely recurrent disease. In addition, psychotherapy is a useful adjunct to antidepressant maintenance therapy in prolonging the duration between recurrent episodes. The currently accepted approach to preventing recurrent depression is to treat the acute episode to full remission and follow up by maintaining the patient on the full, acute dose used to achieve the initial response. The selective serotonin reuptake inhibitors (SSRIs) have been studied in recurrent depression and are rational choices for initial maintenance therapy because of demonstrated efficacy, safety, and tolerance during long-term therapy.

References

Oct 1, 1992·Archives of General Psychiatry·D J KupferV J Grochocinski
Dec 1, 1992·Acta Psychiatrica Scandinavica·S OhrbergB Bahr
Feb 1, 1992·The British Journal of Psychiatry : the Journal of Mental Science·D P Doogan, V Caillard
Dec 1, 1990·Archives of General Psychiatry·E FrankV J Grochocinski
Sep 1, 1989·Therapeutic Drug Monitoring·P J Orsulak
Jan 1, 1993·International Clinical Psychopharmacology·S A Montgomery, G Dunbar

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Citations

Aug 21, 2001·Journal of Affective Disorders·T Riise, A Lund
Jul 1, 1998·European Psychiatry : the Journal of the Association of European Psychiatrists·M VersianiI Figueira
Mar 8, 2007·Evidence-based Complementary and Alternative Medicine : ECAM·Clare WezeGretchen Stevens
Jun 1, 1996·Journal of the American Academy of Child and Adolescent Psychiatry·K FreeC Zahn-Waxler
Apr 7, 2010·Drug Design, Development and Therapy·Trevor R Norman, James S Olver
Jan 5, 2016·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Anne Clark-RaymondAngelos Halaris
Jan 1, 1997·International Journal of Psychiatry in Clinical Practice·G S Malhi, P K Bridges
Apr 28, 2007·Australasian Psychiatry : Bulletin of Royal Australian and New Zealand College of Psychiatrists·David HorganMichael Berk
Feb 9, 2013·The British Journal of Psychiatry : the Journal of Mental Science·Latif MoradveisiArnoud Arntz
Sep 5, 2001·The British Journal of Psychiatry. Supplement·R M Hirschfeld
Jan 1, 2006·International Journal of Psychiatry in Clinical Practice·David S Baldwin

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