PMID: 11319741Apr 25, 2001Paper

Long-term measurement of bone strain in vivo: the rat tibia

Journal of Biomedical Materials Research
B A RabkinB P Halloran

Abstract

Despite the importance of strain in regulating bone metabolism, knowledge of strains induced in bone in vivo during normal activities is limited to short-term studies. Biodegeneration of the bond between gauge and bone is the principle cause of this limitation. To overcome the problem of bond degeneration, a unique calcium phosphate ceramic (CPC) coating has been developed that permits long-term attachment of microminiature strain gauges to bone. Using this technique, we report the first long-term measurements of bone strain in the rat tibia. Gauges, mounted on the tibia, achieved peak or near peak bonding at 7 weeks. Measurements were made between 7-10 weeks. Using ambulation on a treadmill, the pattern and magnitude of strain measured in the tibia remained relatively constant between 7-10 weeks post implantation. That strain levels were similar at 7 and 10 weeks suggests that gauge bonding is stable. These data demonstrate that CPC-coated strain gauges can be used to accurately measure bone strain for extended periods, and provide an in vivo assessment of tibial strain levels during normal ambulation in the rat.

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Citations

Apr 2, 2008·Calcified Tissue International·Alessandro RubinacciGastone Marotti
Feb 3, 2007·Journal of Materials Science. Materials in Medicine·Murat Cavit CehreliKivanc Akca
Mar 7, 2007·Medical & Biological Engineering & Computing·Murat Cavit CehreliKivanc Akca
Nov 3, 2009·Journal of Biomechanics·W C de JongG E J Langenbach
Sep 17, 2005·Clinical Oral Implants Research·Murat Cavit CehreliKivanc Akca
Nov 26, 2005·Clinical Oral Implants Research·Kivanç AkçaMurat Cavit Cehreli
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Aug 3, 2010·Journal of Biomechanics·Russell P MainMarjolein C H van der Meulen
Sep 23, 2014·Journal of Biomechanics·Marco PiccininiAnselm Wiskott
Aug 18, 2017·The Journal of Endocrinology·Rhonda D Prisby
Mar 15, 2019·PeerJ·Lingwei HuangMikko A J Finnilä
Feb 6, 2004·Journal of Biomedical Materials Research. Part a·John A SzivekDon W DeYoung
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Mar 1, 2014·The Journal of Experimental Biology·Russell P MainMarjolein C H van der Meulen

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