Long-term methadone treatment reduces phosphorylation of CaMKII in rat brain

The Journal of Pharmacy and Pharmacology
Jannike M AndersenJørg Mørland

Abstract

To reveal a possible relationship between a previously reported impairment of novelty seeking in rats exposed to methadone and changes in intracellular molecules related to learning and memory. Expression of phosphorylated Ca²⁺-calmodulin kinase II (pCaMKII), extracellular-signal-regulated kinase 2 (pERK2) and cAMP-responsive element binding protein (pCREB), as well as protein kinase A (PKA), was investigated in rat hippocampus one hour, one day and one week after a three-week methadone administration regime. Studies after an equivalent exposure to morphine, and in the frontal pole, were included for comparison. One day after the last methadone injection the hippocampal level of pCaMKII was significantly reduced. This coincides with a previously reported impairment of novelty seeking. At one hour and one week no significant changes were seen. There was no effect on the other proteins. Morphine affected pCaMKII similarly to methadone. Also in the frontal pole the two drugs reduced pCaMKII one day after the last injection. The impaired novelty seeking previously found in rats administered methadone for three weeks coincides with a reduced level of pCaMKII in the brain. This finding implies that methadone treatment may affect lear...Continue Reading

References

Jan 1, 1991·Psychopharmacology·J W Spain, G C Newsom
Nov 14, 1997·British Journal of Clinical Pharmacology·K WolffG T Tucker
Jul 8, 2000·Addiction·S DarkeW Wickes
Nov 24, 2004·Neuroscience and Biobehavioral Reviews·Jeffrey W DalleyTrevor W Robbins
Apr 23, 2005·Drug and Alcohol Dependence·Miriam Z MintzerMaxine L Stitzer
May 17, 2005·Drug and Alcohol Dependence·Antonio VerdejoMiguel Pérez-García
May 5, 2006·Brain : a Journal of Neurology·S F Cooke, T V P Bliss
Mar 1, 2011·Pharmacology, Biochemistry, and Behavior·Jannike M AndersenJørg Mørland

❮ Previous
Next ❯

Citations

Jan 11, 2013·Case Reports in Rheumatology·Fabio Bonilla-AbadíaCarlos A Cañas
Sep 30, 2014·Peptides·Richard J Bodnar
Dec 18, 2015·Trends in Pharmacological Sciences·Christian P MüllerK Peter Giese
Jul 16, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Laura G RosenSteven R Laviolette
Apr 5, 2014·The Journal of Pharmacology and Experimental Therapeutics·Inger Lise BogenJannike Mørch Andersen
Sep 27, 2018·Frontiers in Pharmacology·Leila Ahmad-MolaeiAbbas Haghparast

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.