Long-term monitoring of intracranial pressure in freely-moving rats; impact of different physiological states.

Fluids and Barriers of the CNS
Sajedeh EftekhariRigmor H Jensen

Abstract

Elevated intracranial pressure (ICP) is observed in association with a range of brain disorders. There is limited insight into the regulatory mechanisms of ICP under physiological conditions, and consequently also under pathological conditions. Thereby, to understand the mechanisms underlying ICP dynamics, precise, valid and long-term ICP recordings are of importance in the preclinical setting. Herein, we used a novel telemetric system for ICP recordings which allowed for long-term recordings in freely-moving rats. The aim was to investigate ICP dynamics under different physiological states and investigate how factors such as surgery/recovery, body position, light-dark, co-housing, weight and anesthesia may influence ICP and its waveforms. A telemetric device was implanted epidurally in rats and signals were recorded continuously for up to 50 days (n = 14). Recording was divided into three experimental periods: a surgical recovery period (RP), a physiological period (PP) and an experimental period (EP). Histology was performed to study the morphology of implanted rats and non-implanted rats (n = 17). For the first time, we can demonstrate continuous ICP recordings in freely-moving and co-housed rats for up to 50 days with a hig...Continue Reading

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Nov 27, 2019·Fluids and Barriers of the CNS·Sajedeh EftekhariRigmor Hoejland Jensen

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