Long-term morbidity in bipolar-I, bipolar-II, and unipolar major depressive disorders

Journal of Affective Disorders
Alberto FortePaolo Girardi

Abstract

Long-term symptomatic status in persons with major depressive and bipolar disorders treated clinically is not well established, although mood disorders are leading causes of disability worldwide. To pool data on long-term morbidity, by type and as a proportion of time-at-risk, based on published studies and previously unreported data. We carried out systematic, computerized literature searches for information on percentage of time in specific morbid states in persons treated clinically and diagnosed with recurrent major depressive or bipolar I or II disorders, and incorporated new data from one of our centers. We analyzed data from 25 samples involving 2479 unipolar depressive and 3936 bipolar disorder subjects (total N=6415) treated clinically for 9.4 years. Proportions of time ill were surprisingly and similarly high across diagnoses: unipolar depressive (46.0%), bipolar I (43.7%), and bipolar II (43.2%) disorders, and morbidity was predominantly depressive: unipolar (100%), bipolar-II (81.2%), bipolar-I (69.6%). Percent-time-ill did not differ between UP and BD subjects, but declined significantly with longer exposure times. The findings indicate that depressive components of all major affective disorders accounted for 86% o...Continue Reading

References

Jan 1, 1985·European Archives of Psychiatry and Neurological Sciences·G WinokurJ Angst
Sep 26, 2001·Archives of General Psychiatry·U OsbyP Sparén
Nov 28, 2001·Psychological Medicine·H BrodatyG Andrews
Apr 10, 2002·Acta Psychiatrica Scandinavica·Ravi Lingam, Jan Scott
Jun 5, 2002·Archives of General Psychiatry·Lewis L JuddMartin B Keller
Aug 2, 2003·The International Journal of Neuropsychopharmacology·Lewis L JuddMartin Keller
Dec 16, 2003·Journal of Affective Disorders·Godehard OepenEliot Slater
Jan 20, 2004·The Journal of Clinical Psychiatry·Anton C M VergouwenFrank Koerselman
Apr 2, 2004·The British Journal of Psychiatry : the Journal of Mental Science·Noel KennedyEugene S Paykel
May 5, 2004·The British Journal of Psychiatry : the Journal of Mental Science·T B UstünC J L Murray
Aug 5, 2004·The Journal of Clinical Psychiatry·Tarja K MelartinErkki T Isometsä
Aug 2, 2006·The British Journal of Psychiatry : the Journal of Mental Science·Eugene S PaykelJan Scott
Jan 20, 2007·International Journal of Geriatric Psychiatry·Koen Van der KooyAartjan Beekman
Nov 14, 2007·Acta Psychiatrica Scandinavica·L TondoR J Baldessarini
Feb 7, 2008·The Journal of Clinical Psychiatry·K Mikael HolmaErkki T Isometsä
Feb 28, 2009·Journal of Affective Disorders·Jenny YiendTom Burns
Mar 3, 2009·Journal of Affective Disorders·Shannon Hughes, David Cohen
Mar 20, 2009·Psychological Medicine·W CoryellM Keller
Aug 12, 2009·Journal of Affective Disorders·Arun V RavindranUNKNOWN Canadian Network for Mood and Anxiety Treatments (CANMAT)
Aug 14, 2009·Journal of Affective Disorders·Raymond W LamUNKNOWN Canadian Network for Mood and Anxiety Treatments (CANMAT)
Oct 3, 2009·The American Journal of Psychiatry·William CoryellLewis L Judd
Dec 31, 2009·Human Psychopharmacology·Lesley BerkMichael Berk
Apr 30, 2010·Journal of Affective Disorders·Ross J BaldessariniMauricio Tohen
Jun 23, 2010·Bipolar Disorders·Ross J BaldessariniMauricio Tohen
Sep 29, 2011·Journal of Affective Disorders·R J BaldessariniM Tohen
Nov 17, 2011·Psychological Medicine·K A RiihimäkiE T Isometsä
Dec 16, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Juan Undurraga, Ross J Baldessarini
Apr 13, 2012·CNS Drugs·Alexandre Duarte GiganteLakshmi N Yatham
Apr 18, 2012·The Australian and New Zealand Journal of Psychiatry·Marie CroweLynere Wilson
Sep 8, 2012·The British Journal of Psychiatry : the Journal of Mental Science·Abebaw FekaduAnthony J Cleare

❮ Previous
Next ❯

Citations

Nov 12, 2015·Acta Psychiatrica Scandinavica·L TondoR J Baldessarini
Mar 16, 2016·Proceedings of the National Academy of Sciences of the United States of America·Qian RenKenji Hashimoto
Aug 5, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Gustavo H VázquezRoss J Baldessarini
Jul 15, 2015·The International Journal of Neuropsychopharmacology·Kang SimRoss J Baldessarini
Jun 5, 2015·Journal of Affective Disorders·Gustavo H VázquezRoss J Baldessarini
Aug 21, 2016·Current Psychiatry Reports·Leonardo Tondo, Ross J Baldessarini
Feb 10, 2017·Psychotherapy and Psychosomatics·Ross J BaldessariniGustavo H Vázquez
Apr 15, 2017·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Béatrice WeberChristine Mirabel-Sarron
Apr 20, 2017·Archives of Suicide Research : Official Journal of the International Academy for Suicide Research·Matthew S MichaelsThomas E Joiner
Jun 29, 2018·Psychological Medicine·Rudolf UherErkki Isometsä
Sep 14, 2017·Expert Opinion on Drug Safety·Maurizio PompiliPaolo Girardi
Feb 13, 2019·Expert Review of Neurotherapeutics·Renee-Marie Ragguett, Roger S McIntyre
May 10, 2019·American Journal of Psychotherapy·Danielle M Novick, Holly A Swartz
Jul 18, 2019·Current Medical Research and Opinion·Roger S McIntyre, Joseph R Calabrese
Oct 1, 2020·Psychodynamic Psychiatry·Silvia W OlarteCésar A Alfonso
Apr 27, 2016·Molecular Psychiatry·L Tondo, R J Baldessarini
May 10, 2017·Clinical Drug Investigation·Gabriele SaniLeonardo Tondo
Apr 4, 2017·European Psychiatry : the Journal of the Association of European Psychiatrists·G SerraR J Baldessarini
Apr 22, 2018·Molecular Psychiatry·Ross J BaldessariniGustavo H Vázquez
Oct 15, 2019·The Journal of Pharmacy and Pharmacology·Victor Celso Cavalcanti CapibaribeFrancisca Cléa Florenço de Sousa
Jul 23, 2019·International Journal of Bipolar Disorders·Leonardo TondoUNKNOWN International Group for Studies of Lithium (IGSLi)
Dec 5, 2018·Early Intervention in Psychiatry·Giulia SerraRoss J Baldessarini
Oct 24, 2019·Expert Opinion on Pharmacotherapy·Gayatri SarafLakshmi N Yatham
Jan 7, 2020·International Journal of Bipolar Disorders·Ross J BaldessariniLeonardo Tondo
Oct 6, 2020·Journal of the American Association of Nurse Practitioners·Donna RolinCharles B Montano
Oct 11, 2020·Bipolar Disorders·Leonardo TondoRoss J Baldessarini
Dec 16, 2020·Journal of Affective Disorders·Jun IshigookaTeruhiko Higuchi
Jul 13, 2020·Psychiatry Research·Gianluca SerafiniMario Amore
Jan 24, 2020·Journal of Affective Disorders·Willie R EarleyLakshmi N Yatham
Jan 13, 2021·Translational Psychiatry·Jose Guzman-ParraMarcella Rietschel

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