Long-Term Mortality in HIV-Infected Individuals 50 Years or Older: A Nationwide, Population-Based Cohort Study

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Rebecca LegarthNiels Obel

Abstract

Although the prevalence of HIV-infection among individuals ≥50 years of age has increased, the impact of HIV-infection on risk of death in this population remains to be established. Our aim was to estimate long-term mortality among HIV-infected individuals who were 50 years or older, when compared with an individually-matched cohort from the background population. Population-based cohort-study including HIV-infected individuals ≥50 years, who were alive 1 year after HIV-diagnosis (n = 2440) and a comparison cohort individually-matched by age and gender extracted from the background population (n = 14,588). Cumulative survival was evaluated using Kaplan-Meier method and Mortality Rate Ratios (MRRs) were estimated using Cox Regression Models. Study period 1996-2014. Estimated median survival time from age 50 years for HIV-infected individuals increased from 11.8 years (95% CI: 10.2 to 14.5) during 1996-1999 to 22.8 years (20.0-24.2) in 2006-2014. MRR decreased with increasing age from 3.8 (3.1-4.7) for 50-55 years to 1.6 (1.0-2.6) for 75-80 years. In a cohort of well-treated HIV-infected individuals ≥50 years without AIDS-defining events or comorbidity at study inclusion (n = 517). MRR was 1.7 (1.2-2.3) compared with population c...Continue Reading

References

Jan 18, 2007·Annals of Internal Medicine·Nicolai LohseNiels Obel
Jul 17, 2007·Clinics in Geriatric Medicine·Vera P Luther, Aimee M Wilkin
Jul 11, 2008·AIDS·UNKNOWN Collaboration of Observational HIV Epidemiological Research Europe (COHERE) Study GroupJens Lundgren
Sep 19, 2008·International Journal of Epidemiology·Niels ObelHenrik T Sørensen
Apr 29, 2009·PLoS Medicine·Martin W G BrinkhofUNKNOWN International Epidemiological Databases to Evaluate AIDS (IeDEA)
Jun 17, 2009·BMJ : British Medical Journal·Kelly A Gebo
Sep 11, 2010·AIDS·Keri N AlthoffUNKNOWN North American AIDS Cohorts Collaboration on Research, Design (NA-ACCORD)
Apr 28, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Nicolai LohseNiels Obel
Aug 4, 2011·Scandinavian Journal of Public Health·Carsten Bøcker Pedersen
Aug 4, 2011·Scandinavian Journal of Public Health·Elsebeth LyngeMatejka Rebolj
Apr 12, 2012·International Journal of Epidemiology·UNKNOWN Collaboration of Observational HIV Epidemiological Research Europe (COHERE) in EuroCoordGeneviève Chêne
May 23, 2012·AIDS Research and Human Retroviruses·José R BlancoUNKNOWN CoRIS
Jan 12, 2013·AIDS Patient Care and STDs·Alan T Rodriguez-PenneyUNKNOWN HIV Neurobehavioral Research Program HNRP Group
Oct 19, 2013·PLoS Medicine·Amanda MocroftUNKNOWN Collaboration of Observational HIV Epidemiological Research Europe (COHERE) study in EuroCoord
May 16, 2014·Current Opinion in HIV and AIDS·Dominique Costagliola

❮ Previous
Next ❯

Citations

May 20, 2016·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Dietrich Haubenberger, David B Clifford
Apr 2, 2016·The Journal of Infectious Diseases·Andrew N PhillipsTimothy B Hallett
Aug 16, 2016·PloS One·Adam TrickeyUNKNOWN Antiretroviral Therapy Cohort Collaboration (ART-CC)
Sep 10, 2016·AIDS Patient Care and STDs·Raphael J LandovitzArleen A Leibowitz
Sep 15, 2016·The Journal of Infectious Diseases·Peter W HuntMark J Siedner
Mar 14, 2017·Virulence·Esteban Martinez
Mar 10, 2017·Virulence·Marco RipaGiuseppe Tambussi
Aug 25, 2017·Journal of Women's Health·Emma L FrazierAnn Do
Sep 14, 2018·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Andreas RonitSusanne D Nielsen
Nov 22, 2018·Current Opinion in Infectious Diseases·Tess E Peterson, Jason V Baker
Jul 25, 2019·International Journal of STD & AIDS·Jungmin ParkAlexandra A García
Sep 19, 2019·Revista brasileira de enfermagem·Anna Cláudia Freire de Araújo PatrícioRichardson Augusto Rosendo da Silva
Nov 13, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Sarah M ZaidanUNKNOWN Canadian HIV and Aging Cohort Study
Dec 4, 2019·Current Opinion in Infectious Diseases·Dag Henrik ReikvamBirgitte Stiksrud
Jan 3, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marco GelpiMarius Trøseid
Jul 2, 2016·Current Opinion in HIV and AIDS·Keri N AlthoffAmy C Justice
Aug 31, 2020·Oral Diseases·Paul L FidelMichael E Hagensee
Apr 26, 2016·Oral Diseases·M John
Oct 28, 2017·Infectious Diseases in Obstetrics and Gynecology·Alexandra AserlindJoNell Potter
Feb 6, 2020·Therapeutic Advances in Infectious Disease·James CutrellRoger Bedimo
Dec 15, 2017·PloS One·David S ZingmondArleen A Leibowitz
May 5, 2017·AIDS·Caroline A Sabin, Peter Reiss
Oct 30, 2020·Frontiers in Immunology·Malene Hove-SkovsgaardSusanne Dam Nielsen
Feb 7, 2021·BMC Infectious Diseases·Henning DrechslerRoger Bedimo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.