Long-term mortality with cardiac resynchronization therapy in the Cardiac Resynchronization-Heart Failure (CARE-HF) trial

European Journal of Heart Failure
John ClelandJean-Claude Daubert

Abstract

The Cardiac Resynchronization-Heart Failure (CARE-HF) study helped establish an important role for cardiac resynchronization therapy (CRT) in the management of selected patients with heart failure. We now report the long-term outcome during and subsequent to the randomized trial. Enrollment was completed in March 2003. After reporting the main study results in 2005, investigators were asked to inform patients of the results and implant a CRT device if still appropriate. Subsequently, investigators were asked to consent patients for long-term follow-up until 30 September 2009. Of 813 patients originally enrolled, 343 (42%) died prior to re-consent, 111 patients (14%) were not or could not be contacted, 50 (6%) were alive but declined to participate, and 309 (38%) consented to long-term follow-up. Of patients originally assigned to the control group, > 95% of survivors had received CRT by the time of re-consent. From the time of randomization, 222 patients originally assigned to pharmacological therapy and 192 originally assigned to CRT were known to have died. The hazard ratio for mortality in patients originally assigned to CRT compared with those originally assigned to the control group was 0.77 (95% confidence interval 0.63-0...Continue Reading

Associated Clinical Trials

References

Jun 2, 2001·The New England Journal of Medicine·M PackerUNKNOWN Carvedilol Prospective Randomized Cumulative Survival Study Group
Aug 21, 2001·European Journal of Heart Failure·J G ClelandUNKNOWN CARE-HF study Steering Committee and Investigators
Jun 14, 2002·The New England Journal of Medicine·William T AbrahamUNKNOWN MIRACLE Study Group. Multicenter InSync Randomized Clinical Evaluation
May 21, 2004·The New England Journal of Medicine·Michael R BristowUNKNOWN Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) Investigators
Feb 11, 2005·European Journal of Heart Failure·J G F ClelandUNKNOWN CARE-HF study Steering Committee and Investigators
Mar 9, 2005·The New England Journal of Medicine·John G F ClelandUNKNOWN Cardiac Resynchronization-Heart Failure (CARE-HF) Study Investigators
Nov 29, 2008·Journal of the American College of Cardiology·Cecilia LindeUNKNOWN REVERSE (REsynchronization reVErses Remodeling in Systolic left vEntricular dysfunction) Study Group
Jan 27, 2009·European Heart Journal·Gerhard WikstromUNKNOWN CARE-HF study investigators
Feb 21, 2009·European Journal of Heart Failure·UNKNOWN CRT Survey Scientific Committee
Sep 3, 2009·European Heart Journal·Kenneth DicksteinUNKNOWN National Coordinators
Sep 3, 2009·The New England Journal of Medicine·Arthur J MossUNKNOWN MADIT-CRT Trial Investigators
Oct 27, 2010·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Kenneth DicksteinUNKNOWN ESC Committee for Practice Guidelines
Nov 16, 2010·The New England Journal of Medicine·Anthony S L TangUNKNOWN Resynchronization-Defibrillation for Ambulatory Heart Failure Trial Investigators

❮ Previous
Next ❯

Citations

Jul 9, 2013·European Heart Journal·Ole A Breithardt
Jun 27, 2013·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·UNKNOWN European Society of Cardiology (ESC)Panos E Vardas
Mar 17, 2015·JACC. Heart Failure·John G F Cleland, Charles Butcher
Apr 1, 2014·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Christian ReitanRasmus Borgquist
Nov 15, 2011·Heart Failure Reviews·John G F Cleland, Stefano Ghio
Jan 3, 2016·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Aharon MedinaIlan Goldenberg
Sep 24, 2013·Heart Failure Clinics·John G F ClelandBenjamin Dicken
Jan 1, 2016·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Alexander RomanovEvgeny Pokushalov
Dec 2, 2015·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Oguz KaracaFethi Kilicaslan
Nov 22, 2013·European Journal of Heart Failure·S M Afzal SohaibDarrel P Francis
Jan 28, 2014·European Journal of Heart Failure·Licette C Y LiuB Daan Westenbrink
Oct 17, 2014·Pacing and Clinical Electrophysiology : PACE·Radosław LenarczykZbigniew Kalarus
Mar 20, 2015·Pacing and Clinical Electrophysiology : PACE·Christian ReitanRasmus Borgquist
May 10, 2016·Expert Review of Medical Devices·M Seifert, C Butter
Sep 30, 2016·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·D O VerschureH J Verberne
Jun 19, 2017·JACC. Heart Failure·John G F ClelandMark C Petrie
Aug 26, 2017·Medical & Biological Engineering & Computing·Nuria OrtigosaAntonio Galbis
Dec 9, 2017·Heart·Panagiota Anna Chousou, Peter J Pugh
Nov 12, 2014·Journal of the American Heart Association·Faisal M MerchantLeslie A Saxon
Sep 5, 2015·Circulation. Arrhythmia and Electrophysiology·Tomas RoubicekRostislav Polasek
Oct 20, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Michael D Taylor, Shelby Kutty
Feb 18, 2020·Journal of Cardiovascular Electrophysiology·Thomas G MiddourDaniel P Morin
Apr 12, 2017·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Martin SeifertChristian Butter
Dec 10, 2017·Pacing and Clinical Electrophysiology : PACE·Kebei LiJiangang Zou
May 19, 2019·International Journal of Molecular Sciences·Márcio Galindo KiuchiMarkus P Schlaich
Dec 8, 2019·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Dennis LawinUNKNOWN members of the European CRT Survey II of the EHRA/HFA/ESC

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.