Long-term, multidomain analyses to identify the breed and allelic effects in MSTN-edited pigs to overcome lameness and sustainably improve nutritional meat production.

Science China. Life Sciences
Ziyao FanKui Li

Abstract

Beef and mutton production has been aided by breeding to integrate allelic diversity for myostatin (MSTN), but a lack of diversity in the MSTN germplasm has limited similar advances in pig farming. Moreover, insurmountable challenges with congenital lameness and a dearth of data about the impacts of feed conversion, reproduction, and meat quality in MSTN-edited pigs have also currently blocked progress. Here, in a largest-to-date evaluation of multiple MSTN-edited pig populations, we demonstrated a practical alternative edit-site-based solution that overcomes the major production obstacle of hindlimb weakness. We also provide long-term and multidomain datasets for multiple breeds that illustrate how MSTN-editing can sustainably increase the yields of breed-specific lean meat and the levels of desirable lipids without deleteriously affecting feed-conversion rates or litter size. Apart from establishing a new benchmark for the data scale and quality of genome-edited animal production, our study specifically illustrates how gene-editing site selection profoundly impacts the phenotypic outcomes in diverse genetic backgrounds.

References

Dec 14, 1985·The Veterinary Record·C Sutherland
Nov 14, 1997·Proceedings of the National Academy of Sciences of the United States of America·A C McPherron, S J Lee
Oct 6, 1999·Current Opinion in Genetics & Development·S J Lee, A C McPherron
Aug 24, 2001·Journal of Animal Science·J W Keele, S C Fahrenkrug
Mar 5, 2002·Nature Biotechnology·Yifan DaiDavid L Ayares
Jun 25, 2004·The New England Journal of Medicine·Markus SchuelkeSe-Jin Lee
Mar 9, 2005·Journal of Animal Science·E KanisJ A M van Arendonk
Jul 1, 2005·Science in China. Series C, Life Sciences·Zhengquan YuNing Li
Mar 23, 2012·Animal : an International Journal of Animal Bioscience·J W M MerksE F Knol
May 1, 2010·Animal : an International Journal of Animal Bioscience·I KolkmanD Lips
Nov 16, 2012·Nature·Martien A M GroenenLawrence B Schook
Feb 26, 2014·Proceedings of the National Academy of Sciences of the United States of America·Petr HavlíkAn Notenbaert
Jul 3, 2015·Nature·David Cyranoski
Nov 14, 2015·Scientific Reports·Kankan WangDaxin Pang
Sep 22, 2016·Science Advances·Fuminori TaniharaTakeshige Otoi
Mar 5, 2017·BMC Biology·Ryan G WalkerThomas B Thompson
Oct 11, 2017·Transgenic Research·Kankan WangDaxin Pang
Jan 14, 2018·The EMBO Journal·Thomas R CottonMarko Hyvönen
Oct 24, 2018·Nutrients·Ewa Sokoła-WysoczańskaBożena Patkowska-Sokoła

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