Long-term naltrexone treatment normalizes the pituitary response to gonadotropin-releasing hormone in polycystic ovarian syndrome

Fertility and Sterility
A LanzoneS Mancuso

Abstract

To investigate the influence of opioid system on the exaggerated LH response to GnRH test in the polycystic ovarian syndrome (PCOS). Pituitary stimulation (GnRH 100 micrograms) in a group of PCOS patients under basal condition and after 4 weeks of treatment with naltrexone. In the PCOS group, the naltrexone treatment determines a significant reduction of the LH response (calculated as the area under curve) to GnRH test, with a similar significant decrease of the LH:FSH. Naltrexone normalizes in the PCOS group the pituitary response to GnRH test, abolishing every statistical differences with the control group.

Citations

Oct 22, 2015·Expert Opinion on Therapeutic Targets·Shruthi Mahalingaiah, Evanthia Diamanti-Kandarakis
Aug 24, 1999·Endocrine Reviews·L PoretskyL C Giudice

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