Long-term neurobehavioral effects of alcohol or nicotine exposure in adolescent animal models

Annals of the New York Academy of Sciences
Craig J SlaweckiCindy L Ehlers

Abstract

Adolescent alcohol and nicotine abuse is common, but its neurodevelopmental consequences remain unclear. This laboratory utilized adolescent rodent models to assess the hypothesis that adolescents are highly susceptible to the effects of alcohol and nicotine. Rats were exposed to ethanol for 10-14 days using an intermittent vapor inhalation paradigm. Rats were continuously exposed to nicotine for 5 days using Nicoderm CQ transdermal patches. Alcohol or nicotine exposure altered neurobehavioral function when assessed after 3-7 weeks of abstinence. Alcohol-induced changes include increased electroencephalographic (EEG) frequency, decreased amplitude of the cortical N1 and hippocampal P3 event-related potential (ERP) components, enhanced anxiety-like behavior, and enhanced depressive-like behavior. Nicotine-induced changes include decreased slow-wave cortical EEG power, increased cortical N1 ERP amplitude, decreased motor activity, and increased anxiety-like behavior. These findings support the hypothesis that adolescents are uniquely susceptible to the effects of chronic alcohol and nicotine exposure.

References

May 19, 2000·Neuroscience and Biobehavioral Reviews·L P Spear
May 18, 2001·Brain Research. Developmental Brain Research·C J SlaweckiC L Ehlers
Apr 18, 2002·Alcohol·Craig J Slawecki, Michelle Betancourt
Apr 20, 2002·Alcoholism, Clinical and Experimental Research·Craig J Slawecki
Sep 18, 2002·Brain Research. Developmental Brain Research·Craig J Slawecki, Cindy L Ehlers
Oct 31, 2002·Journal of the International Neuropsychological Society : JINS·Susan F TapertSandra A Brown
Jul 23, 2003·Pharmacology, Biochemistry, and Behavior·Craig J SlaweckiCindy L Ehlers

❮ Previous
Next ❯

Citations

Aug 29, 2006·Psychopharmacology·Francesco MussoGeorg Winterer
Feb 23, 2013·Cell and Tissue Research·Miriam Schneider
May 4, 2011·Behavioral Neuroscience·Tamara L Doremus-Fitzwater, Linda P Spear
Apr 27, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yael Abreu-VillaçaCláudio C Filgueiras
May 3, 2014·Pharmacology, Biochemistry, and Behavior·Anita DesikanCindy L Ehlers
Mar 16, 2011·Behavioural Brain Research·Anderson Ribeiro-CarvalhoYael Abreu-Villaça
Feb 26, 2008·Child and Adolescent Psychiatric Clinics of North America·Christian KielingFrancisco X Castellanos
Jun 19, 2008·Neurotoxicology and Teratology·Mary Anne Hutchison, Anthony L Riley
Nov 14, 2006·Pharmacology, Biochemistry, and Behavior·Marc W FüllgrabeRainer Spanagel
Jul 28, 2005·Alcoholism, Clinical and Experimental Research·Sören SiegmundRainer Spanagel
Oct 6, 2005·Alcoholism, Clinical and Experimental Research·Susan BarronLinda P Spear
Nov 5, 2005·Alcoholism, Clinical and Experimental Research·Craig J Slawecki, Cindy L Ehlers
Jul 26, 2008·Alcoholism, Clinical and Experimental Research·José R CriadoCindy L Ehlers
Jan 9, 2007·Alcoholism, Clinical and Experimental Research·Deborah A DawsonTing-Kai Li
Oct 3, 2008·Alcoholism, Clinical and Experimental Research·Jerry P PianCindy L Ehlers
Nov 24, 2007·Alcoholism, Clinical and Experimental Research·Jaime L Diaz-Granados, Danielle L Graham
Apr 3, 2014·Alcoholism, Clinical and Experimental Research·Abigail G SchindlerJeremy J Clark
Jul 18, 2006·Pharmacology, Biochemistry, and Behavior·Danielle L Graham, Jaime L Diaz-Granados
Oct 22, 2016·Neuroscience and Biobehavioral Reviews·Linda Patia Spear
Sep 30, 2016·Pharmacological Reviews·Fulton T CrewsDonita L Robinson
Jul 28, 2016·Journal of Molecular Neuroscience : MN·Christina J Perry
Sep 14, 2016·Genes, Brain, and Behavior·K M Holleran, D G Winder
Feb 23, 2018·Nature Reviews. Neuroscience·Linda P Spear
Dec 19, 2017·Birth Defects Research·Cheril Tapia-RojasRodrigo A Quintanilla
Jul 25, 2019·Alcoholism, Clinical and Experimental Research·Fulton T CrewsRyan P Vetreno

❮ Previous
Next ❯

Related Concepts

Related Feeds

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.