Long-term neurodevelopment outcome of caffeine versus aminophylline therapy for apnea of prematurity

Journal of Neonatal-perinatal Medicine
S KhuranaLeslie Edward Simon Lewis

Abstract

Methylxanthines are the most commonly prescribed drug in neonatal setups. However, Clinicians show indecision in choosing the right agent for Apnea of Prematurity in most of the developing countries. Present study aimed to compare rate of mortality and survival with normal neurodevelopment outcome at 18 to 24 months of corrected age, between Caffeine- and Aminophylline-treated infants for apnea of prematurity. 240 infants were randomly allocated to caffeine and aminophylline for apnea of prematurity during February 2012 to January 2015. Long-term neurodevelopmental assessment was done only from children who had attained corrected age of 18 to 24 months during April 2014 to February 2016. Cognitive, language and motor deficits were assessed by Bayley Scale of infant and toddler development (BSID - III). Postnatal characteristics such as hearing and visual impairments during NICU stay were noted and same were followed up. Infants allocated to caffeine group showed 83% less risk of getting cognitive impairment (RR 0.16; CI 95% range 0.02 to 1.36), 50% less risk of developing motor deficits (RR 0.50; CI 95% range 0.12 to 1.95) and 24% less risk of developing language problems (RR 0.76; CI 95% range 0.36 to 1.58). However in all the...Continue Reading

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Citations

Aug 8, 2018·Journal of Tropical Pediatrics·Shivakumar MJayashree Purkayastha
Apr 9, 2020·International Journal of Environmental Research and Public Health·Yeyetzi C Torres-UgaldeRebeca M E Guzmán-Saldaña
Nov 5, 2021·Journal of Clinical Pharmacy and Therapeutics·Joseph V PergolizziRobert B Raffa

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