Long-term neuroendocrine effects of iron-deficiency anemia in infancy.

Pediatric Research
Barbara FeltBetsy Lozoff

Abstract

Iron-deficiency anemia (IDA) is recognized to have long-lasting effects on neurodevelopment, but there is little research on neuroendocrine systems. This study examined the effects of IDA in early or later infancy on plasma cortisol and prolactin stress-response patterns for 1 h after a venipuncture and catheter placement in 10-y-old healthy Chilean children. Children identified with IDA at 6 mo (IDA-6; n = 13) or 12 mo (IDA-12; n = 24) and who were iron sufficient (IS) at other infancy time points were compared to children who were IS at all time points during infancy (n = 23). All children received at least 6 mo of oral iron treatment in infancy. At 10 y of age, IDA-6 and IDA-12 children demonstrated altered cortisol response patterns; both showed a more immediate decline and IDA-12 children showed a blunted curvature as compared to IS children. IDA-12 children showed significantly lower cortisol levels at 30 and 45 min after venipuncture and catheter placement than did IS children. There were no significant differences for stress-responsive plasma prolactin patterns between groups. The results indicate that having IDA during infancy is associated with long-term neuroendocrine effects on stress-responsive cortisol patterns.

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Citations

Aug 1, 2015·The Kaohsiung Journal of Medical Sciences·Firat ErdoganIlke Ozahi Ipek
May 8, 2015·Reviews in the Neurosciences·Ioannis BakoyiannisVasilios Pergialiotis
Apr 15, 2015·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S ReyesC Algarin
May 12, 2016·BMC Public Health·Haroldo da Silva FerreiraRisia Cristina Egito de Menezes
Jun 1, 2017·Journal of Pediatric Hematology/oncology·Kristiyana KanevaMichael J Kelly
Oct 25, 2017·Nutritional Neuroscience·Gloria A OteroGustavo G Mendieta
Apr 11, 2014·The Journal of Nutrition·Betsy LozoffJulie Sturza
Mar 4, 2015·The Journal of Nutrition·Mari S Golub, Casey E Hogrefe
May 13, 2020·BMC Medicine·Andrew J ForgieBenjamin P Willing

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