PMID: 6112769Jan 1, 1981Paper

Long-term neuroleptic treatment of chronic schizophrenic patients: clinical and biochemical effects of withdrawal

Psychopharmacology
K J ZanderM Ackenheil

Abstract

In 17 chronic schizophrenic patients under chronic neuroleptic treatment for 13 years, a 30-day drug withdrawal resulted in early relapse of four patients, slight deterioration in five, and slight amelioration in eight patients. No incidence of neuroleptic symptoms such as tardive dyskinesia occurred. Prolactin in plasma and cerebrospinal fluid (CSF), not being elevated under chronic treatment, decreased significantly after 30 days of withdrawal. Homovanillic acid and 3-methoxy-4-hydroxyphenylglycol in CSF ranged normally and did not change during withdrawal. In contrast, plasma noradrenaline was elevated and decreased after drug discontinuation. No unequivocal relationship between biochemical and psychopathological features was found.

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Citations

Nov 4, 2010·Social Psychiatry and Psychiatric Epidemiology·Yu-Tao XiangGabor S Ungvari
Apr 2, 2008·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Giulio SciglianoFloriano Girotti
Oct 20, 2001·Science and Engineering Ethics·Adil E ShamooPatricia Langenberg
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Sep 1, 1990·The Japanese Journal of Psychiatry and Neurology·M SaraiS Kimura
Dec 1, 1992·Biological Psychiatry·B KirkpatrickC A Tamminga
Feb 7, 2018·The Cochrane Database of Systematic Reviews·Hanna BergmanKarla Soares-Weiser
Jan 27, 2006·The Cochrane Database of Systematic Reviews·K Soares-Weiser, J Rathbone
Mar 1, 1995·The British Journal of Psychiatry : the Journal of Mental Science·U F MaltE Maehlum
Sep 1, 1995·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·E M Waring

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