Long-term neuronal replacement in adult rat hippocampus after status epilepticus despite chronic inflammation

The European Journal of Neuroscience
Sara BondeOlle Lindvall

Abstract

Dentate gyrus (DG) neurogenesis is transiently increased during the first weeks after status epilepticus (SE). Survival of the new neurons is initially compromised by an acute inflammatory response, but the long-term fate of the remaining ones in the post-SE environment is unknown. Here adult rats were subjected to 2 h electrically evoked self-sustained SE and perfused after 5 weeks or 6 months. Rats exhibited partial or generalized SE followed by spontaneous behavioural seizures and abnormal electroencephalographic activity during 6 months. Numbers of activated microglia in the dentate subgranular zone (SGZ)-granule cell layer (GCL) and in the hilus declined after 5 weeks, but were still elevated at 6 months after SE, with no differences between the milder partial and the more severe generalized SE. At 6 months, partial and generalized SE rats showed a seven-fold increase in the number of mature SGZ-GCL neurons formed during the first 2 weeks along with aberrant neurons in the hilus. Total numbers of mature neurons in SGZ-GCL were unaltered, indicating that SE-generated neurons replaced dead granule cells. Neuroblast formation had returned to normal levels in SGZ-GCL but generation of aberrant neurons in the hilus was still on...Continue Reading

References

Mar 1, 1972·Electroencephalography and Clinical Neurophysiology·R J Racine
Sep 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·J BengzonO Lindvall
Aug 26, 1998·Journal of Neurobiology·F H GageJ Ray
Aug 18, 2000·The European Journal of Neuroscience·M G De SimoniA Vezzani
Apr 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·K JinD A Greenberg
Aug 8, 2001·The European Journal of Neuroscience·A ArvidssonO Lindvall
Mar 5, 2002·Nature·Henriette van PraagFred H Gage
Aug 6, 2002·Nature Medicine·Andreas ArvidssonOlle Lindvall
Oct 16, 2002·Glia·Yoshinori Imai, Shinichi Kohsaka
Apr 30, 2003·The Journal of Comparative Neurology·Alexandre G DayerHeather A Cameron
Jun 25, 2003·Experimental Neurology·Karin BorgesRaymond Dingledine
Oct 24, 2003·The Journal of Comparative Neurology·Jason P BrownH Georg Kuhn
Oct 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·Christine T EkdahlOlle Lindvall
Jan 28, 2004·Annual Review of Pharmacology and Toxicology·D Chichung LieFred H Gage
Jul 15, 2004·Advances in Experimental Medicine and Biology·Helen E Scharfman
Jul 28, 2004·Brain & Development·Byung Ho ChaGregory L Holmes
Jan 19, 2005·The European Journal of Neuroscience·Sebastien Couillard-DespresLudwig Aigner
Jul 19, 2005·Neurobiology of Disease·Arielle CrespelMireille Lerner-Natoli
Jul 29, 2005·Annals of Neurology·Terhi J PirttiläAsla Pitkänen

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Citations

Jul 28, 2012·Nature Neuroscience·Zaal KokaiaOlle Lindvall
Aug 21, 2007·Nature Reviews. Neuroscience·Maurice A CurtisPeter S Eriksson
Oct 14, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jean-Pierre LouboutinDavid S Strayer
Jul 17, 2008·Epilepsia·Bharathi Hattiangady, Ashok K Shetty
Feb 7, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yukari Shigemoto-MogamiKaoru Sato
May 24, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael S Hester, Steve C Danzer
Sep 22, 2012·Stem Cells International·Bruno P CarreiraInês M Araújo
Jan 16, 2016·Current Neurology and Neuroscience Reports·Qin ZhongFeng-Ru Tang
Feb 24, 2012·Pharmacological Reports : PR·Marta Andres-MachJarogniew J Łuszczki
Jun 16, 2009·Journal of Neuropathology and Experimental Neurology·Jean-Pierre LouboutinDavid S Strayer
Jun 23, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Linda JanssonAnders Tingström
May 27, 2015·Glia·Kaoru Sato
Sep 18, 2008·Epilepsy & Behavior : E&B·Ramkumar KurubaAshok K Shetty
Jul 30, 2008·Neuroscience·C T EkdahlO Lindvall
May 9, 2008·Journal of Neuroendocrinology·S A Wolf, O Ullrich
Sep 3, 2011·Neuropathology and Applied Neurobiology·E-L von RüdenH Potschka
Jan 1, 2014·Experimental Neurology·Marta Perez-AlcazarMarcela Pekna
Apr 25, 2012·Psychoneuroendocrinology·Harris Eyre, Bernhard T Baune
Oct 5, 2010·Seizure : the Journal of the British Epilepsy Association·Luciana D'AlessioJuan José López-Costa
Oct 21, 2009·Neuron·Pamela A Carpentier, Theo D Palmer
Jun 28, 2016·Journal of Neuroinflammation·Matilda AhlChristine T Ekdahl
Oct 30, 2016·Epilepsy Research·Jian-Xin LiuYong Liu
Nov 14, 2016·Journal of the Neurological Sciences·Aline Silva de MirandaAntônio Lúcio Teixeira
Mar 17, 2017·Frontiers in Neuroscience·Fabricio N MendonçaAntônio-Carlos G Almeida

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