LONG-TERM NONOPERATIVE RATE OF THYROID NODULES WITH BENIGN RESULTS ON THE AFIRMA GENE EXPRESSION CLASSIFIER.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Jennifer SiposJulie Ann Sosa

Abstract

The primary objective was to assess the operative rate in patients with a benign result from the Afirma gene expression classifier (GEC) during long-term follow-up at nonacademic medical facilities. The secondary endpoint of this study was the treating physician's opinion regarding the safety of GEC use compared to the hypothetical situation of providing thyroid nodule management without the GEC. This was a retrospective study of nonacademic medical practices utilizing the GEC. Those clinicians utilizing the GEC testing who had three or more 'benign' results during the data collection period (September 2010 through June 2014) were invited to participate. Operative status and patient demographics were documented for patients with GEC testing at least 36 months (± 3 months) prior to the date of data collection. A survey also was administered to the treating physicians to assess their perceived safety of using the GEC in patient care. During 36 months (± 3 months) of follow-up, 17 of 98 patients (17.3%) with a 'benign' GEC result underwent surgery. Within the first 2 years after a 'benign' GEC, 88% of surgeries were performed. Regarding safety of the GEC, the treating physicians reported that patient safety was improved by using t...Continue Reading

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Citations

May 4, 2017·Archives of Pathology & Laboratory Medicine·Grant HarrisonXiaoyin Jiang
Jul 26, 2017·Thyroid : Official Journal of the American Thyroid Association·Quan-Yang DuhGregory Randolph
Jan 18, 2018·Archives of Pathology & Laboratory Medicine·Michiya Nishino, Marina Nikiforova
Feb 26, 2019·Thyroid : Official Journal of the American Thyroid Association·Trevor E AngellEllen Marqusee
Jun 4, 2019·Thyroid : Official Journal of the American Thyroid Association·Mayumi EndoJennifer A Sipos
Oct 5, 2017·Cancer Control : Journal of the Moffitt Cancer Center·Pablo Valderrabano, Bryan McIver
Dec 27, 2017·Cancer·Mara Y RothDavid L Steward
Aug 11, 2020·The Journal of Clinical Endocrinology and Metabolism·Mayumi EndoFadi Nabhan
Apr 6, 2021·Thyroid : Official Journal of the American Thyroid Association·Michiya NishinoJames V Hennessey
Jun 18, 2021·The Journal of Clinical Endocrinology and Metabolism·Abberly Lott Limbach, Jennifer A Sipos

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