Long-term nonprogressive disease among untreated HIV-infected individuals: clinical implications of understanding immune control of HIV

JAMA : the Journal of the American Medical Association
Stephen A Migueles, Mark Connors

Abstract

As of 2008, more than 33 million adults and children have been estimated to be living with human immunodeficiency virus (HIV). Among them are rare patients (<0.5%) who have remained clinically well without antiretroviral therapy after almost 20 years of infection. They maintain stable CD4 cell counts and suppressed HIV replication to levels comparable with those measured in patients receiving combination antiretroviral therapy. No known epidemiologic or behavioral factors are predictive of untreated, nonprogressive HIV infection; however, host genetics and immune response factors, most specifically HLA antigen class I-restricted HIV-specific CD8 T cells, appear to be primarily responsible for this remarkable phenotype in a majority of these individuals. These patients offer hope that durable control of HIV infection is possible and can provide important insight to inform the development of the next generation of HIV/AIDS vaccines and immune-based therapies. This article reviews clinical features of these unique patients and discusses them in the context of nonprogressors enrolled in other cohorts. Potential mechanisms underlying nonprogressive HIV infection and scientific discoveries, facilitated by the participation of these p...Continue Reading

Citations

Nov 5, 2013·The Journal of Infectious Diseases·Sonya KrishnanIrini Sereti
Feb 23, 2011·Future Virology·C David PauzaRobert R Redfield
Nov 10, 2010·Retrovirology·Maria SalgadoJoel N Blankson
Jun 4, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Olusimidele T AkinsikuPaul A Goepfert
Aug 30, 2011·Proceedings of the National Academy of Sciences of the United States of America·Karen A O'ConnellJoel N Blankson
Sep 17, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Nadeera SidiqueShyam Kottilil
Feb 4, 2012·AIDS·Yue YangMathias Lichterfeld
Mar 15, 2011·Current Opinion in HIV and AIDS·Adam R HerspergerMark Connors
Nov 11, 2010·AIDS·George B Cohen
Mar 16, 2016·Scientific Reports·Mohamed El-FarUNKNOWN Investigators of the Canadian HIV+ Slow Progressor Cohort
Apr 18, 2015·The Journal of Infectious Diseases·Kelly A Metcalf PateJoel N Blankson
May 23, 2014·The Linacre Quarterly·Christian BruggerRita L Marker
Apr 19, 2015·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Theodros S TsegayeEllen N Kersh
May 21, 2015·Nature Immunology·Tae-Wook ChunAnthony S Fauci
May 20, 2015·Nature Immunology·Stephen A Migueles, Mark Connors
Apr 25, 2014·The Journal of the Association of Nurses in AIDS Care : JANAC·José CôtéCécile Tremblay
Jun 23, 2012·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Mariam Al-FadhliRaj Raghupathy
Jan 7, 2017·AIDS·Genevieve E MartinUNKNOWN the SPARTAC Trial Investigators
Jun 17, 2014·Vaccines·Georgia D Tomaras, Barton F Haynes
Oct 2, 2012·Nature·Philip A MuddDavid I Watkins
Aug 25, 2017·Future Microbiology·Megan E MayJoel N Blankson

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