Long-term observation of patients with anti-neutrophil cytoplasmic antibody-associated vasculitis treated with rituximab

Rheumatology
R StasiD Provan

Abstract

Rituximab, a chimeric anti-CD20 monoclonal antibody, has been shown to be quite effective in the treatment of immune disorders resulting from autoantibodies. We prospectively studied the long-term effects of rituximab in 10 patients with anti-neutrophil cytoplasmic antibody (ANCA)-positive vasculitis refractory to conventional therapy (n=3) or in second or subsequent relapse (n=7). The median age of patients was 53 yrs (range 38-70 yrs). Eight were classified as Wegener's granulomatosis, and two as microscopic polyangiitis. Clinical activity was assessed using the Birmingham Vasculitis Activity Score modification for Wegener's granulomatosis. Treatment consisted of intravenous infusions of rituximab given at the dose of 375 mg/m2 weekly for four consecutive weeks. All patients experienced a rapid clinical improvement following the administration of rituximab, with nine complete responses and one partial response at 6 months. With a median follow-up of 33.5 months (range 26-45 months), three patients have thus far relapsed. Retreatment with the monoclonal antibody at the same dose and schedule resulted in a new sustained response in all these patients. Rituximab therapy resulted in prolonged B-cell depletion. The ANCA titres dec...Continue Reading

References

Mar 15, 1992·Annals of Internal Medicine·G S HoffmanA S Fauci
Feb 1, 1994·Arthritis and Rheumatism·J C JennetteC G Kallenberg
Apr 25, 2001·Arthritis and Rheumatism·J H StoneUNKNOWN International Network for the Study of the Systemic Vasculitides (INSSYS)
Feb 1, 2003·Blood·Francesco ZajaGianfranco Ferraccioli
Apr 1, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Anthony D BoothUNKNOWN Pan-Thames Renal Research Group
Jun 10, 2003·Arthritis and Rheumatism·Gregg J Silverman, Stuart Weisman
Jul 4, 2003·The New England Journal of Medicine·David JayneUNKNOWN European Vasculitis Study Group
Jun 18, 2004·The New England Journal of Medicine·Jonathan C W EdwardsTim Shaw
Nov 20, 2004·Annals of the Rheumatic Diseases·J-E GottenbergUNKNOWN Club Rheumatismes et Inflammation (CRI)
Jan 25, 2005·Nephron. Clinical Practice·Maria KallenbachTroels Ring
Mar 1, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Alistair J FerraroCaroline O Savage
Apr 21, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Claude BachmeyerRenato Demontis
Sep 2, 2005·Scandinavian Journal of Rheumatology·R OmdalG Kristoffersen

❮ Previous
Next ❯

Citations

Mar 30, 2010·Rheumatology International·J C HenesI Koetter
Aug 26, 2010·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Arnd HeiligenhausGerhild Wildner
Oct 22, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Michael Walsh, David Jayne
Apr 25, 2009·Clinical Rheumatology·J BrunnerL B Zimmerhackl
Apr 28, 2011·Clinical Rheumatology·Frances ReesPeter Lanyon
Nov 1, 2011·Modern Rheumatology·Chethana Dharmapalaiah, Richard A Watts
Feb 14, 2008·Clinical Reviews in Allergy & Immunology·Laurent Sailler
Feb 14, 2008·Clinical Reviews in Allergy & Immunology·Achille AoubaLoïc Guillevin
Jan 4, 2008·Clinical Reviews in Allergy & Immunology·Claas H Hinze, Robert A Colbert
Jan 9, 2008·Clinical Reviews in Allergy & Immunology·Andreea Coca, Jennifer H Anolik
Feb 2, 2008·Clinical Reviews in Allergy & Immunology·A KesselE Toubi
Jul 24, 2008·Nature Clinical Practice. Rheumatology·Oliver Flossmann, David R W Jayne
Oct 7, 2010·Nature Reviews. Rheumatology·Min Chen, Cees G M Kallenberg
Jul 22, 2010·The New England Journal of Medicine·Rachel B JonesUNKNOWN European Vasculitis Study Group
Dec 17, 2008·Current Opinion in Rheumatology·Sharon A Chung, Philip Seo
Nov 18, 2011·Current Opinion in Rheumatology·Rodrigo Cartin-CebaUlrich Specks
Mar 14, 2012·Current Opinion in Rheumatology·Abraham Rutgers, Cees G M Kallenberg
Nov 12, 2009·Journal of Paediatrics and Child Health·Flora McErlane, Liza J McCann
Nov 7, 2008·Nephrology·Solomon MenahemUNKNOWN Caring for Australians with Renal Impairment (CARI)
Nov 21, 2007·Annals of the Rheumatic Diseases·D E FurstM E Weinblatt
Sep 27, 2007·The British Journal of Ophthalmology·Julie FreidlinNisha Acharya
May 12, 2007·Critical Care : the Official Journal of the Critical Care Forum·Spyros A PapirisCharis Roussos
May 15, 2012·Journal of the American Society of Nephrology : JASN·Alberto MagnascoGian Marco Ghiggeri
Apr 6, 2007·Internal Medicine·Naoto TamuraYoshinari Takasaki
Jan 5, 2008·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Tomoki OriguchiKatsumi Eguchi
May 26, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Eugene P RheeJohn L Niles
May 14, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Pietro RavaniGian Marco Ghiggeri
Mar 13, 2014·Rheumatology·Tabitha Turner-StokesMark A Little
Oct 16, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Federico Alberici, David R W Jayne
Sep 27, 2014·BMC Medical Informatics and Decision Making·Raluca CozmutaLiana Fraenkel
Aug 11, 2007·Current Rheumatology Reports·Carol A Langford
Nov 20, 2009·Current Rheumatology Reports·Vijay R Karia, Luis R Espinoza
Mar 20, 2015·Expert Review of Clinical Immunology·Alireza GhanadanNima Rezaei
Dec 2, 2008·Expert Opinion on Pharmacotherapy·Clive Kelly, Vadivelu Saravanan
Aug 9, 2011·Expert Opinion on Biological Therapy·Petra M MeinersHendrika Bootsma
Mar 8, 2014·Advances in Chronic Kidney Disease·Ladan ZandFernando C Fervenza
May 6, 2010·Chest·Abigail R Lara, Marvin I Schwarz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.