Long-term omega-3 fatty acid supplementation prevents expression changes in cochlear homocysteine metabolism and ameliorates progressive hearing loss in C57BL/6J mice

The Journal of Nutritional Biochemistry
Raquel Martínez-VegaIsabel Varela-Nieto

Abstract

Omega-3 polyunsaturated fatty acids (PUFAs) are essential nutrients well known for their beneficial effects, among others on cognitive development and maintenance, inflammation and oxidative stress. Previous studies have shown an inverse association between high plasma levels of PUFAs and age-related hearing loss, and the relationship between low serum folate and elevated plasma homocysteine levels and hearing loss. Therefore, we used C57BL/6J mice and long-term omega-3 supplementation to evaluate the impact on hearing by analyzing their auditory brainstem response (ABR) and distortion product otoacoustic emissions (DPOAE) thresholds. The omega-3 group showed significantly lower ABR hearing thresholds (~25 dB sound pressure level) and higher DPOAE amplitudes in mid-high frequencies when compared to the control group. These changes did not correlate with alterations between groups in plasma homocysteine or serum folate levels as measured by high-performance liquid chromatography and a microbiological method, respectively. Aging in the control group was associated with imbalanced cytokine expression toward increased proinflammatory cytokines as determined by quantitative reverse transcriptase polymerase chain reaction; these chan...Continue Reading

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Citations

Sep 16, 2016·Frontiers in Aging Neuroscience·Raquel Martínez-VegaMaría A Pajares
Dec 1, 2017·Antioxidants & Redox Signaling·María A Pajares, Dolores Pérez-Sala
Sep 29, 2018·Scandinavian Journal of Clinical and Laboratory Investigation·Bodil BjørndalRolf K Berge
Dec 28, 2018·Nutrients·Ana M PugaTeresa Partearroyo
Nov 28, 2019·BMC Research Notes·Yohei HonkuraNoriko Osumi
May 11, 2017·Frontiers in Molecular Neuroscience·Teresa PartearroyoIsabel Varela-Nieto
Aug 23, 2020·Free Radical Biology & Medicine·Ignacio A Cortés FuentesJuan G Gormaz
Jul 2, 2021·Nutrition & Metabolism·Christine BrüttingGabriele I Stangl

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