Long-Term Oncological and Functional Outcomes of Partial Nephrectomy in Solitary Kidneys

Clinical Genitourinary Cancer
Csaba BercziTibor Flasko

Abstract

In this study we assessed the efficacy of nephron-sparing surgery and the changes in renal function after surgery in patients with solitary kidneys. From January 2000 to January 2015, 50 patients with solitary kidneys underwent partial nephrectomy for renal cancer. In 34 of the patients the contralateral kidneys had been removed previously because of renal tumor. The mean age of the patients was 62 ± 10 years. There were 15 women and 35 men. The average diameter of the tumors was 35.2 ± 19.5 mm. The mean preoperative aspects and dimensions used for an anatomical classification score was 7.6 ± 0.7. The mean renal ischemia time was 13.8 ± 6.5 minutes. The mean preoperative and the early postoperative glomerular filtration rate (GFR) were 62 ± 21 mL/min/1.73 m(2) and 44 ± 18 mL/min/1.73 m(2) (P = .0001), respectively. The mean GFR values decreased by 29% at 1 and at 3 years, and by 36% at 5 years after surgery. All changes in postoperative GFR levels were significant compared with the preoperative values. The tumor size and the warm ischemia time were risk factors for the long-term renal function. The mean follow-up time was 106 ± 96 months. During this period local recurrence occurred in 1 patient, and distant metastases were dia...Continue Reading

References

Jul 4, 2001·The Journal of Urology·R G Uzzo, A C Novick
May 25, 2005·Journal of Endourology·Dinesh SinghInderbir S Gill
Aug 2, 2005·Journal of Endourology·Erik S Weise, Howard N Winfield
Jun 19, 2007·The Journal of Urology·Inderbir S GillAndrew C Novick
Jan 29, 2008·The Journal of Urology·Brian R LaneInderbir S Gill
Mar 21, 2009·The Journal of Urology·Jeffrey La RochelleArie Belldegrun
Nov 17, 2009·The Journal of Urology·Inderbir S GillMihir M Desai
Jul 14, 2010·World Journal of Urology·Daniel J LeeJames M McKiernan
Mar 20, 2012·The Journal of Urology·Matthew N SimmonsSteven C Campbell
Nov 20, 2012·The Journal of Urology·Matthew N SimmonsSteven C Campbell
Mar 19, 2013·The Journal of Urology·Christina B ChingAmr F Fergany
Jan 27, 2015·European Urology·Borje LjungbergAxel Bex

❮ Previous
Next ❯

Citations

Dec 17, 2016·Acta Cirúrgica Brasileira·Gustavo Ruschi BecharaDiogo Benchimol De Souza
Jun 8, 2017·Acta Cirúrgica Brasileira·José Aurelino Damasceno-FerreiraDiogo Benchimol De Souza
Feb 27, 2020·American Journal of Surgery·Gabriela F Buys-GonçalvesDiogo B De Souza
Apr 14, 2021·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Gabriela F Buys GonçalvesDiogo Benchimol de Souza

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.