Long-term ongoing coagulopathy in premature infants with respiratory distress syndrome

Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Muammer BuyukinanNilgun Kultursay

Abstract

The previously reported activated intravascular coagulation system in the acute phase of respiratory distress syndrome (RDS) has not been evaluated in the long term. We assessed the activities of coagulation system of a cohort of premature infants with RDS in comparison with healthy premature infants (HPIs), healthy mature infants (HMIs), and pediatric laboratory controls over a 6-month period. Cord and venous blood samples were taken at birth, at the first month and sixth month. Protein C (PC), free protein S (f-PS), and antithrombin (AT) activities, thrombin-antithrombin (TAT) complex, prothrombin fragment 1 + 2 (PF1 + 2), and fibrinogen levels were measured. Mean PC, f-PS, d-dimer, and fibrinogen values were similar at all periods for HPI and RDS groups. Low neonatal anticoagulant proteins increased within 6 months in HMI and HPI groups. However, in RDS group, the AT activity remained significantly lower together with significantly higher TAT and PF1 + 2 levels both at the first month and at sixth month, suggesting a long-term consumption coagulopathy.

References

Aug 1, 1992·The American Review of Respiratory Disease·R M ViscardiS Idell
Apr 1, 1992·The American Review of Respiratory Disease·B SchmidtR Roberts
Jan 1, 1990·The American Journal of Pediatric Hematology/oncology·M AndrewM Johnston
Jan 1, 1994·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·B K Schmidt
May 1, 1997·Archives of Disease in Childhood. Fetal and Neonatal Edition·U Nowak-GöttlU Göbel
Nov 14, 1997·Acta Paediatrica·A MautoneD De Mattia
Mar 29, 2002·American Journal of Hematology·Murat YurdakökSule Yigit
May 20, 2006·Thrombosis Research·Dirk Bassler, Barbara Schmidt

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Methods Mentioned

BETA
enzyme-linked immunosorbent assays
lavage

Software Mentioned

SPSS

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